Multiple viral coinfections among HIV/AIDS patients in China
Multiple viral coinfections among HIV/AIDS patients in China
复制标题
中国艾滋病毒/艾滋病患者中多种病毒合并感染
DOI：
10.5582/bst.2011.v5.1.1
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发表时间：
2011-01-01
影响因子：
5.5
通讯作者：
Detels, Roger
中科院分区：
文献类型：
--
作者：
He, Na;Chen, Li;Detels, Roger
采用横断面调查方法，对我国HIV/AIDS患者中B肝炎病毒（HBV）、丙型肝炎病毒（HCV）、EB病毒（EBV）、单纯疱疹病毒1型（HSV-1）和2型（HSV-2）混合感染的流行病学特征进行了研究。共分析了山西（中部地区，n = 287）、浙江（东部地区，n = 163）、云南（西南地区，n = 300）和新疆（西北地区，n = 360）四个省份的1，110例HIV/AIDS患者。HBsAg、抗HCV、抗EBV、抗HSV-1和抗HSV-2抗体阳性率分别为6.3%、59.0%、96.6%、91.5%和34.1%。同时感染5种病毒者11例（1.0%），同时感染4种病毒者177例（15.9%），同时感染3种病毒者611例（55.0%），同时感染2种病毒者288例（25.9%），同时感染1种病毒者23例（2.1%），同时感染5种病毒者1例（0.1%）。多因素Logistic回归分析显示，HBV、EBV和HSV-1合并感染与社会人口学特征和HIV传播方式无关，HCV合并感染与地理区域、年龄、性别、种族、婚姻状况和HIV传播方式有关，而HSV-2合并感染与地理区域、种族和HIV传播方式有关。本研究提示，不同地区、不同社会人口学背景和不同传播方式的HIV/AIDS患者合并病毒感染情况不同，应在相关卫生保健项目中予以区别对待。
A cross-sectional survey was conducted to determine seroprevalence and correlates of coinfections of hepatitis B virus (HBV), hepatitis C virus (HCV), Epstein-Bar virus (EBV), herpes simplex virus including type 1 (HSV-1) and type 2 (HSV-2) among human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients in China. A total of 1,110 HIV/AIDS patients from Shanxi (Central area, n = 287), Zhejiang (Eastern area, n = 163), Yunnan (Southwestern area, n = 300) and Xinjiang (Northwestern area, n = 360) provinces were analyzed. The overall seroprevalence was 6.3% for HBsAg, 59.0% for anti-HCV IgG, 96.6% for anti-EBV IgG, 91.5% for anti-HSV-1 IgG, and 34.1% for anti-HSV-2 IgG. Eleven (1.0%) HIV/AIDS patients were coinfected with all five viruses, 177 (15.9%) with four viruses, 611 (55.0%) with three viruses, 288 (25.9%) with two viruses, 23 (2.1%) with single virus, and 1 (0.1%) with none of the five viruses. Multiple logistic regression analyses indicated that neither HBV, nor EBV and HSV-1 coinfection was associated with sociodemographic characteristics and HIV transmission mode, but HCV coinfection was associated with geographic region, age, gender, ethnicity, marital status, and HIV transmission mode, whereas HSV-2 coinfection was associated with geographic region, ethnicity and HIV transmission mode. This study suggests that HIV/AIDS patients with different regional and sociodemographic backgrounds and HIV transmission mode in China have different profiles of viral coinfections and should be subject to differential considerations in related health care programs.