Role of surgery in the prophylaxis of hereditary cancer syndromes
Role of surgery in the prophylaxis of hereditary cancer syndromes
复制标题
手术在预防遗传性癌症综合征中的作用
DOI：
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发表时间：
2002
影响因子：
3.7
通讯作者：
E. Tsianos
中科院分区：
文献类型：
--
作者：
D. Roukos;A. Kappas;E. Tsianos
实体瘤的常规手术治疗最近呈下降趋势。随着早期发现率和微创治疗率的稳步提高，内窥镜和腹腔镜技术正日益取代传统手术。癌前病变和早期小癌症局限于沿整个胃肠道沿着的粘膜层，从食管和胃到结直肠，现在可以通过微创技术治愈性切除，大大提高了许多患者的生活质量。相比之下，传统的手术切除特定器官，以保护个人在非常高的风险发展遗传性癌症的乳腺癌，结肠癌和胃癌越来越受到相当大的关注。然而，尽管手术是能够消除特定器官癌症风险的唯一预防性干预措施，但手术预防一直存在争议，原因和问题有很多。在这里，我们讨论预防性手术的好处和障碍。遗传性癌症综合征是罕见的。它们占所有病例的不到5%，因为大多数乳腺癌、结肠癌或胃腺癌都是零星发生的。这些综合征包括遗传性非息肉病性结肠癌综合征、Peutz-Jeghers综合征、Cowden综合征以及受Li-Fraumeni综合征和家族性腺瘤性息肉病影响的某些运动障碍。1已发现BRCA 1和BRCA 2基因突变，8年
Conventional surgery in the treatment of solid tumors suggests a recently declining trend. Endoscopic and laparoscopic techniques are increasingly replacing traditional surgery as both rates of early detection and minimal invasive treatment are steadily increasing. Premalignant lesions and early-stage small cancers confined to the mucosal layer along the whole gastrointestinal tract, from esophagus and stomach to the colorectum, can now curatively be resected by minimally invasive techniques substantially improving the quality of life of many patients. In contrast, traditional surgical resection of specific organs for the protection of individuals at very high risk of developing inherited cancer in the breast, colon, and stomach is increasingly receiving considerable attention. However, although surgery is the only preventive intervention able to eliminate the risk of cancer at a specific organ, surgical prophylaxis has been controversial, for a numerous amount of reasons and questions have been raised. Here we discuss the benefits and obstacles of prophylactic surgery. Hereditary cancer syndromes are rare. They account for less than 5% of all cases because most breast, colon, or gastric adenocarcinomas occur sporadically. These syndromes include hereditary nonpolyposis colon cancer syndrome, Peutz-Jeghers syndrome, Cowden syndrome, and some kindreds affected with Li-Fraumeni syndrome and familial adenomatous polyposis. 1 Mutations in BRCA1 and BRCA2 genes have been identified, 8 years
影响因子：
158.5
作者：
COLDITZ, GA;WILLETT, WC;HENNEKENS, CH
通讯作者：
HENNEKENS, CH
影响因子：
158.5
作者：
Rebbeck, TR;Lynch, HT;Weber, BL
通讯作者：
Weber, BL