Family history of alcoholism and response to sweets
Family history of alcoholism and response to sweets
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DOI：
10.1097/01.alc.0000093739.05809.dd
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发表时间：
2003-11-01
影响因子：
3.2
通讯作者：
Khalitov, E
中科院分区：
文献类型：
--
作者：
Kampov-Polevoy, AB;Garbutt, JC;Khalitov, E
Background: The relationship between a hedonic response to sweet tastes and a propensity to excessive alcohol drinking is supported by both animal and human studies. This study was designed to test the hypothesis that the genetic risk for alcoholism as measured by a paternal history of alcoholism in young social drinkers is associated with sweet-liking, defined as rating the strongest offered sucrose solution (i.e., 0.83 M) as the most palatable during the standard sweet test.Methods: Participants were 163 subjects (39% male) without a lifetime history of alcohol or drug abuse or dependence. Eighty-one subjects had a paternal history of alcoholism (FH+), and 82 did not (FH-). Each subject rated a series of sucrose solutions for intensity of sweetness and palatability. Subjects were categorized as sweet-likers if they rated the highest sucrose concentration as the most pleasurable.Results: The estimated odds of being a sweet-liker were 2.5 times higher for FH+ than for FH- subjects. FH+ subjects disliked the tastes of the two weakest offered sucrose concentrations (0.05 and 0.10 M), whereas FH- subjects reported these tastes to be neutral.Conclusions: The results of this study support the hypothesis that sweet-liking is associated with a genetic vulnerability to alcoholism.
