Computer-based system for the virtual-endoscopic guidance of bronchoscopy
Computer-based system for the virtual-endoscopic guidance of bronchoscopy
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DOI：
10.1016/j.cviu.2006.10.010
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发表时间：
2007-10-01
影响因子：
4.5
通讯作者：
Higgins, W. E.
中科院分区：
文献类型：
--
作者：
Helferty, J. P.;Sherbondy, A. J.;Higgins, W. E.
诊断肺癌的标准程序包括两个阶段：三维(3D)计算机断层扫描(CT)图像评估，随后是介入性支气管镜检查。一般来说，医生在3D CT图像评估结果和后续支气管镜检查之间没有联系。因此，医生基本上是盲目地对可疑的癌症部位进行支气管镜活检。我们设计了一个基于计算机的系统，在支气管镜检查中极大地增强了医生的视力。该系统使用计算机图形学和计算机视觉技术来实现详细的3D CT程序规划和后续图像引导的支气管镜检查。通过三维CT数据和支气管镜视频的实时配准和融合，手术计划直接链接到支气管镜手术。在手术过程中，该系统提供了许多可视化工具、融合的CT-视频数据和定量距离测量；这为医生提供了大量关于如何操纵支气管镜以及在哪里插入活检针的视觉反馈。该系统的核心是基于归一化互信息的CT视频配准技术。几组结果验证了配准技术的有效性。此外，我们还给出了一系列针对幻影、动物和人类肺癌患者的完整系统的测试结果。结果表明，不仅在技能水平上存在差异，而且不同项目之间的差异也不同。与标准程序相比，该系统大大减少了医生的数量，但活组织检查的有效性增加了。(C)2007 Elsevier Inc.保留所有权利。
The standard procedure for diagnosing lung cancer involves two stages: three-dimensional (3D) computed-tomography (CT) image assessment, followed by interventional bronchoscopy. In general, the physician has no link between the 3D CT image assessment results and the follow-on bronchoscopy. Thus, the physician essentially performs bronchoscopic biopsy of suspect cancer sites blindly. We have devised a computer-based system that greatly augments the physician's vision during bronchoscopy. The system uses techniques from computer graphics and computer vision to enable detailed 3D CT procedure planning and follow-on image-guided bronchoscopy. The procedure plan is directly linked to the bronchoscope procedure, through a live registration and fusion of the 3D CT data and bronchoscopic video. During a procedure, the system provides many visual tools, fused CT-video data, and quantitative distance measures; this gives the physician considerable visual feedback on how to maneuver the bronchoscope and where to insert the biopsy needle. Central to the system is a CT-video registration technique, based on normalized mutual information. Several sets of results verify the efficacy of the registration technique. In addition, we present a series of test results for the complete system for phantoms, animals, and human lung-cancer patients. The results indicate that not only is the variation in skill level between different. physicians greatly reduced by the system over the standard procedure, but that biopsy effectiveness increases. (C) 2007 Elsevier Inc. All rights reserved.