Heart rate mediation of sex differences in pain tolerance in children
Heart rate mediation of sex differences in pain tolerance in children
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DOI：
10.1016/j.pain.2005.08.008
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发表时间：
2005-11-01
期刊：
影响因子：
7.4
通讯作者：
Naliboff, BD
中科院分区：
文献类型：
--
作者：
Lu, Q;Zeltzer, LK;Naliboff, BD
尽管有证据支持疼痛存在与性别相关的重要差异，但支撑这种差异的机制尚不清楚。本研究的目的是检查健康儿童的自主神经唤醒和对实验室疼痛刺激的疼痛耐受性方面的性别与青春期差异之间的关系。我们测试了以下具体假设：（1）女性比男性具有更强的自主神经唤醒和更少的疼痛耐受性，（2）这种疼痛耐受性的性别差异将由自主神经唤醒介导。参与者为 244 名健康儿童（50.8% 为女性，平均年龄 12.73 +/- 2.98 岁，范围 8-18 岁）。皮肤压力和热痛刺激的单独 4 个试验块以平衡顺序呈现。在每个区块之前的 2-3 分钟内以及试验之间的 1 分钟内记录心率 (HR)。结果表明，与男性相比，女性对皮肤压力的耐受性较低，但对热痛的耐受性较低。此外，女性的试验前 HR 高于男性。中介分析表明，压痛耐受性的性别差异是由试验前 HR 的性别差异造成的。对青春期也有显着影响，但这些影响并不因性别而异。总体而言，与青春期后期的儿童相比，青春期早期儿童在不同性行为中的皮肤压力和热痛方面具有更高的试验前 HR 和更低的疼痛耐受性。这些结果表明，自主神经唤醒可能是儿童疼痛反应中性别相关差异的中介因素。 (c) 2005 年国际疼痛研究协会。由 Elsevier B.V. 出版。保留所有权利。
Despite evidence supporting the existence of important sex-related differences in pain, the mechanisms underpinning such differences are not well understood. The aim of this study is to examine the relationship between sex and pubertal differences in autonomic arousal and pain tolerance to laboratory pain stimuli in healthy children. We tested the following specific hypotheses: (1) females would have greater autonomic arousal and less pain tolerance than males, and (2) this sex difference in pain tolerance would be mediated by autonomic arousal. Participants were 244 healthy children (50.8% female, mean age 12.73 +/- 2.98 years, range 8-18 years). Separate 4-trial blocks of cutaneous pressure and thermal pain stimuli were presented in counterbalanced order. Heart rate (HR) was recorded during 2-3 min periods preceding each block and a 1-min period between trials. Results indicated lower tolerance in females for cutaneous pressure, but not thermal pain, compared to males. In addition, pre-trial HR was greater for females than males. Mediation analyses Suggested that sex differences in pressure pain tolerance were accounted for by sex differences in pre-trial HR. There were also significant effects for puberty, but these did not vary by sex. Overall, early pubertal children had greater pre-trial HR and less pain tolerance than those in late puberty for both cutaneous pressure and thermal pain across sex. These results suggest that autonomic arousal may be a mediator of sex-related differences in pain responses in children. (c) 2005 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.