Differential Expression of Cytochrome C Oxidase Subunit I Along the Colorectal Adenoma: Carcinoma Progression
Differential Expression of Cytochrome C Oxidase Subunit I Along the Colorectal Adenoma: Carcinoma Progression
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DOI：
10.1097/pai.0000000000000509
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发表时间：
2018-10-01
影响因子：
1.6
通讯作者：
Mostafa, Rabab G.
中科院分区：
文献类型：
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作者：
Hewedi, Iman H.;Farid, Rola M.;Mostafa, Rabab G.
细胞凋亡能力的丧失通常导致基因组不稳定性增强，从而促进癌发生。细胞色素c氧化酶亚基I（CcOI）可以帮助评估石蜡包埋活检组织的凋亡抵抗。共50例结直肠病例，包括10例非肿瘤性结肠切除术的对照病例，15例腺瘤性结直肠息肉和25例结直肠癌，在这项回顾性研究中研究了CcOI的免疫组化表达。评估CcOI的染色模式，并计算异常表达指数为隐窝限制性丢失和总体免疫染色减少（ODI）。在腺癌肿瘤组织中计算的ODI被指定为Tr ODI。CcOI异常表达的隐窝限制性丢失和ODI指数在腺瘤性息肉组（2.5%和47.54%）和腺癌组中的非肿瘤性粘膜（2.78%和49.1%）均显著高于对照组（0.55%和7.32%）（P
Loss in apoptosis competence often results in augmented genomic instability contributing to carcinogenesis. Cytochrome c oxidase subunit I (CcOI) can help assess apoptosis resistance in paraffin-embedded biopsies. In total, 50 colorectal cases including 10 control cases of colectomy for non-neoplastic condition, 15 cases of adenomatous colorectal polyps, and 25 cases of colorectal carcinoma were investigated in this retrospective study for immunohistochemical expression of CcOI. The staining pattern of CcOI was assessed and indices of aberrant expression were calculated as crypt-restricted loss and overall decreased immunostaining (ODI). ODI calculated in the adenocarcinoma tumor tissue was designated as Tr ODI. The crypt-restricted loss and ODI indices of the aberrant CcOI expression are significantly higher in the adenomatous polyps group (2.5% and 47.54%) and in the non-neoplastic mucosa among adenocarcinoma group (2.78% and 49.1%) when they are compared with the control group (0.55% and 7.32%) (P