Influence of Fatty Liver on Plasma Small, Dense LDL-Cholesterol in Subjects with and without Metabolic Syndrome
Influence of Fatty Liver on Plasma Small, Dense LDL-Cholesterol in Subjects with and without Metabolic Syndrome
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DOI：
10.5551/jat.5447
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发表时间：
2011-01-01
影响因子：
4.4
通讯作者：
Yoshino, Gen
中科院分区：
文献类型：
--
作者：
Sugino, Ikumi;Kuboki, Koji;Yoshino, Gen
Aim: Small, dense low density lipoprotein (sLDL) is known as an atherogenic lipoprotein and is often associated with metabolic syndrome (MS). A high frequency of sLDL is found in hypertriglyceridemic subjects. Also, fatty liver (FL) is often associated with MS; therefore, we studied whether the association of FL increases sLDL-cholesterol (C) in subjects with MS.Methods: In total, 207 patients were enrolled in this study and FL was estimated by echogram. The presence of MS was diagnosed according to the Japanese Guidelines for the Definition of Metabolic Syndrome.Results: sLDL-C and sLDL-C/LDL-C in the MS group were higher than in the non-MS group. Also, sLDL-C and sLDL-C/LDL-C in the FL group were higher than in the non-FL group. The simple correlation coefficient (r) between plasma triglyceride and sLDL-C or sLDL-C/LDL-C in all subjects was 0.36 and 0.51. In the MS group, r values were 0.32 and 0.52 while, in the non-FL group, r was 0.32 and 0.38, respectively. Two-way ANOVA revealed that FL was a powerful determinant of plasma sLDL-C and sLDL-C/LDL-C, but MS was not. When we divided all subjects into four groups, i.e., MS(-) FL(-), MS(-) FL(+), MS(+) FL(-) and MS(+) FL(+), sLDL-C/LDL-C of MS(+) FL(+) was significantly higher than all other groups.Conclusion: Association of MS and FL significantly increased sLDL-C and sLDL-C/LDL-C. The significant relationship between sLDL-C/LDL-C and plasma triglyceride in the FL group indicates that FL may produce triglyceride-rich VLDL, a precurser of sLDL, thereby contributing to the appearance of sLDL particles in the plasma of MS patients with FL.
