Modulation of Auditory and Visual Processing by Delta-9-Tetrahydrocannabinol and Cannabidiol: an fMRI Study
Modulation of Auditory and Visual Processing by Delta-9-Tetrahydrocannabinol and Cannabidiol: an fMRI Study
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DOI：
10.1038/npp.2011.17
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发表时间：
2011-06-01
影响因子：
7.6
通讯作者：
McGuire, Philip K.
中科院分区：
文献类型：
--
作者：
Winton-Brown, Toby T.;Allen, Paul;McGuire, Philip K.
虽然大麻对感知的影响有很好的记录，但对其神经基础或这些如何有助于形成精神病症状知之甚少。我们使用功能性磁共振成像（fMRI）来评估健康志愿者在视觉和听觉处理过程中Delta-9-tetrahydrocannabinol（THC）和cannabidiol（CBD）的影响。总共对14名健康志愿者进行了三次扫描。相同的10 mg THC，600 mg CBD和安慰剂胶囊以平衡双盲伪随机交叉设计分配。每种物质的血浆水平、生理参数和精神病理学指标均在基线和摄入物质后定期采集。志愿者被动地听单词阅读，并在功能磁共振成像扫描过程中交替观看放射状视觉棋盘。THC的使用与焦虑，中毒和阳性精神病症状的增加有关，而CBD没有显着的症状影响。与安慰剂相比，THC在听觉处理过程中减少了双侧颞叶皮层的激活，在视觉处理过程中增加和减少了不同视觉区域的激活。在听觉处理过程中，CBD与右颞叶皮层的激活相关，而相比之下，THC和CBD在右后上级颞回（右侧与韦尼克区同源）中具有相反的作用。此外，在听觉处理过程中，THC对该区域激活的衰减（最大值61，-15，-2）与其对精神病症状的急性影响相关。单剂量的THC和CBD以不同的方式调节处理听觉和视觉刺激的区域的脑功能，并与诱发的精神病症状有关。Neuropsychopharmacology（2011）36，1340-1348; doi：10.1038/npp.2011.17; 2011年3月16日在线发表
Although the effects of cannabis on perception are well documented, little is known about their neural basis or how these may contribute to the formation of psychotic symptoms. We used functional magnetic resonance imaging (fMRI) to assess the effects of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) during visual and auditory processing in healthy volunteers. In total, 14 healthy volunteers were scanned on three occasions. Identical 10mg THC, 600mg CBD, and placebo capsules were allocated in a balanced double-blinded pseudo-randomized crossover design. Plasma levels of each substance, physiological parameters, and measures of psychopathology were taken at baseline and at regular intervals following ingestion of substances. Volunteers listened passively to words read and viewed a radial visual checkerboard in alternating blocks during fMRI scanning. Administration of THC was associated with increases in anxiety, intoxication, and positive psychotic symptoms, whereas CBD had no significant symptomatic effects. THC decreased activation relative to placebo in bilateral temporal cortices during auditory processing, and increased and decreased activation in different visual areas during visual processing. CBD was associated with activation in right temporal cortex during auditory processing, and when contrasted, THC and CBD had opposite effects in the right posterior superior temporal gyrus, the right-sided homolog to Wernicke's area. Moreover, the attenuation of activation in this area (maximum 61, -15, -2) by THC during auditory processing was correlated with its acute effect on psychotic symptoms. Single doses of THC and CBD differently modulate brain function in areas that process auditory and visual stimuli and relate to induced psychotic symptoms. Neuropsychopharmacology (2011) 36, 1340-1348; doi:10.1038/npp.2011.17; published online 16 March 2011