BMP-15 regulation of ovulation quota in mammals.
BMP-15 regulation of ovulation quota in mammals.
复制标题
BMP-15 对哺乳动物排卵配额的调节。
DOI：
10.1111/j.1447-0578.2006.00148.x
复制
发表时间：
2006
影响因子：
3.4
通讯作者：
Shimasaki,Shunichi
中科院分区：
文献类型：
--
作者：
Shimasaki,Shunichi
Naturally occurring mutations in the oocyte-specific factor, bone morphogenetic protein-15 (BMP-15), cause infertility in women and in ewes. In contrast to these monoovulatory mammals, the targeted deletion of BMP-15 in polyovulatory mice results in subfertility with only minimal defects in the ovulation process. Given the established role of BMP-15 in governing the progression of folliculogenesis, it is hypothesized that species-specific differences in the BMP-15 system are involved in species-specific determination of ovulation quota and litter size. Recent data usingin vitrocell transfection methodology indicate that, in contrast to human BMP-15 which is successfully processed and secreted, the mouse BMP-15 proprotein is resistant to proteolytic cleavage. Thus, no functional mature BMP-15 is secretedin vitro. Further studies have shown that the functional mature form of BMP-15 is barely detectable in mouse oocytesin vivountil just before ovulation, when it is markedly increased. The general hypothesis to emerge from these observations is that the species-specific differences in the defects caused by mutations in thebmp15 gene between monoovulatory ewes and women and polyovulatory mice might be attributed to the timing of the production of BMP-15 mature protein.
