Somatosensory evoked potentials associated with thermal activation of type II Aδ mechanoheat nociceptive afferents
Somatosensory evoked potentials associated with thermal activation of type II Aδ mechanoheat nociceptive afferents
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DOI：
10.3109/00207450009035011
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发表时间：
2000-01-01
影响因子：
2.2
通讯作者：
Fei, DY
中科院分区：
文献类型：
--
作者：
Harkins, SW;Price, DD;Fei, DY
我们评估了诱发电位(EP)对传递到健康成年人多毛皮肤的有害接触热脉冲的影响。从34摄氏度的适应温度到52摄氏度的目标温度的热脉冲产生了两个头皮正向波。第一次峰值出现在44-45摄氏度(类似于刺激开始后的500ms)，第二次峰值出现在52℃热脉冲后的300ms(类似于刺激开始后的1 S)。在39摄氏度的适应温度下，没有出现第一个正波，这表明温暖和/或低阈值机械热传入失去了同步激活。第二次诱发电位是在两种适应温度刺激后观察到的，并与第一次疼痛的主观报告有关。臂部和腿部痛觉诱发电位潜伏期差值与伤害性传入神经传导一致(接近10/ms)。对疼痛接触热刺激的EPS在评估小纤维周围神经病和评估改变的疼痛状态方面可能有价值。
We evaluated evoked potentials (EPs) to noxious contact heat pulses delivered to hairy skin of healthy adults. Heat pulses from an adapting temperature of 34 degrees C to a target temperature of 52 degrees C, produced two scalp positive waves. The first peaked at 44 degrees to 45 degrees C (similar to 500 ms following stimulus onset), while the second peaked similar to 300 ms following the 52 degrees C heat pulse (similar to 1 s after stimulus onset). The first positive wave was absent from an adapting temperature of 39 degrees C, suggesting loss of synchronized activation of warm and/or low threshold mechanothermal afferents. The second EP was observed following stimulation from both adapting temperatures and was associated with subjective report of first pain. Latency difference of the pain EP from arm and leg were consistent with conduction in AS nociceptive afferents (similar to 10/ms). EPs to painful contact thermal stimuli may be of value in the evaluation of small fiber peripheral neuropathies and assessment of altered pain states.