The utility of circulating LHCGR as a predictor of Down's syndrome in early pregnancy.
The utility of circulating LHCGR as a predictor of Down's syndrome in early pregnancy.
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DOI：
10.1186/1471-2393-14-197
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发表时间：
2014-06-06
影响因子：
3.1
通讯作者：
Gratacos E
中科院分区：
文献类型：
--
作者：
Chambers AE;Mills WE;Mercadé I;Crovetto F;Crispi F;Bodi LR;Pugia M;Mira A;Lasalvia L;Banerjee S;Casals E;Gratacos E
既往研究表明，血清或血浆中可溶性LHCGR/hCG-sLHCGR浓度联合PAPP-A和游离βhCG可显著提高孕早期唐氏综合征筛查的敏感性，而不改变假阳性率。本研究的目的是进一步研究sLHCGR形式作为组合标记物的作用，并研究sLHCGR是否可以作为唐氏综合征的独立生物标志物在妊娠早期筛查。本文对40例唐氏综合征孕妇和300例正常孕妇进行了PAPP-A、游离β-hCG和hCG-sLHCGR的测定。在40唐氏和206对照妊娠sLHCGR浓度进行了分析。hCG-LHCGR联合PAPP-A和游离βhCG可提高检出率（DR）35%，而不改变假阳性率（FPR）。sLHCGR：hCG-sLHCGR比率单独检测80%的孕早期筛查唐氏妊娠，假阳性率为0.5%。虽然sLHCGR形式与PAPP-A和游离βhCG的组合测量显著增加了孕早期唐氏综合征的检出率，但sLHCGR：hCG-sLHCGR的比率作为独立标志物，其检出率显著高于用于产前孕早期唐氏综合征筛查的现有生化标志物。
Previous studies showed that soluble LHCGR/hCG-sLHCGR concentrations in serum or plasma combined with PAPP-A and free βhCG significantly increased the sensitivity of Down’s syndrome screen at early pregnancy without altering the false positive rate. The goal of the present study was to further examine the role of sLHCGR forms as combinatorial markers and to investigate whether sLHCGR could serve as an independent biomarker for Down’s syndrome in first trimester pregnancy screens. The PAPP-A, free βhCG, and hCG-sLHCGR concentrations together with nuchal translucency (NT) were measured in 40 Down’s and 300 control pregnancies. The sLHCGR concentration was analysed in 40 Down’s and 206 control pregnancies. The hCG-LHCGR in combination with PAPP-A and free βhCG increased the detection rate (DR) by 35% without altering the false positive rate (FPR). The sLHCGR: hCG-sLHCGR ratio alone detected 80% of Down’s pregnancies in first trimester screening, with a false positive rate of 0.5%. While measurement of sLHCGR forms in combination with PAPP-A and free βhCG significantly increases the detection rate of Down’s syndrome at first trimester, the ratio of sLHCGR: hCG-sLHCGR acts as an independent marker with a detection rate that is significantly higher than the existing biochemical markers individually for prenatal first trimester screening of Down’s syndrome.
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影响因子：
3
作者：
Benn, Peter;Borrell, Antoni;Yaron, Yuval
通讯作者：
Yaron, Yuval
DOI：
10.1073/pnas.0808319105
发表时间：
2008-10-21
影响因子：
11.1
作者：
Fan, H. Christina;Blumenfeld, Yair J.;Quake, Stephen R.
通讯作者：
Quake, Stephen R.
影响因子：
6.1
作者：
Kagan, Karl O.;Wright, Dave;Nicolaides, Kypros H.
通讯作者：
Nicolaides, Kypros H.
影响因子：
4.4
作者：
Banerjee, S;Smallwood, A;Nicolaides, K
通讯作者：
Nicolaides, K
影响因子：
4.8
作者：
Pidoux, Guillaume;Gerbaud, Pascale;Frendo, Jean-Louis
通讯作者：
Frendo, Jean-Louis