H-2M3 PRESENTS A LISTERIA-MONOCYTOGENES PEPTIDE TO CYTOTOXIC LYMPHOCYTES-T
H-2M3 PRESENTS A LISTERIA-MONOCYTOGENES PEPTIDE TO CYTOTOXIC LYMPHOCYTES-T
复制标题
DOI：
10.1016/0092-8674(92)90097-v
复制
发表时间：
1992-07-24
期刊：
影响因子：
64.5
通讯作者：
BEVAN, MJ
中科院分区：
文献类型：
--
作者：
PAMER, EG;WANG, CR;BEVAN, MJ
我们报告的证据表明，主要组织相容性复合物编码的非经典 I 类分子在感染期间向细胞毒性 T 淋巴细胞 (CTL) 呈递外源肽。用有毒力的单核细胞增生李斯特氏菌免疫的小鼠产生具有α-β受体的CD8+CTL，该受体对由主要组织相容性复合体的M区编码的保守I类分子呈递的细菌肽具有特异性。李斯特菌肽可被羧肽酶 Y 消化，但能抵抗氨肽酶 M，并且只有具有 N-甲酰基蛋氨酸的肽才能竞争性阻断其向 CTL 的呈递。用 H-2M3d ene 转染可使阴性 (H-2w17) 细胞系呈递细菌肽。因此，H-2M3 的一项功能是在感染期间将细菌肽呈递给 CTL。
We report evidence that a major histocompatibility complex-encoded nonclassic class I molecule presents a foreign peptide to cytotoxic T lymphocytes (CTL) during an infection. Mice immunized with virulent Listeria monocytogenes generate CD8+ CTL with alpha-beta receptors specific for a bacterial peptide presented by a conserved class I molecule encoded in the M region of the major histocompatibility complex. The Listeria peptide is digested by carboxypeptidase Y but resists aminopeptidase M, and only peptides with N-formyl methionine competitively block its presentation to CTL. Transfection with the H-2M3d ene enables a negative (H-2w17) cell line to present the bacterial peptide. One function, therefore, of H-2M3 is to present bacterial peptides to CTL during infection.