Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus
Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus
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DOI：
10.4049/jimmunol.175.10.6829
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发表时间：
2005-11-15
影响因子：
4.4
通讯作者：
Sigal, LJ
中科院分区：
文献类型：
--
作者：
Fang, M;Sigal, LJ
人们认为CD8(+)T淋巴细胞或抗体可以独立清除许多原发病毒感染，包括由正痘病毒(OPV)引起的感染，正痘病毒是包括人类病原体天花和猴痘以及疫苗种牛痘病毒的一个属。然而，大多数关于抗体和CD8(+)T细胞在保护中的作用的实验都使用了非宿主特有的病毒。在本研究中，我们使用小鼠特异性OPV ectromelia病毒和CD40、B细胞或CD8(+)T细胞缺陷的小鼠以及过继转移CD8(+)T或B淋巴细胞来表明CD8(+)T细胞提供的保护是不完整的。尽管持续的CD8(+)T细胞反应，在缺乏抗体反应的情况下，皮疹病毒仍然存在。这会导致疾病延迟，并无情地导致死亡。因此，CD8(+)T淋巴细胞和抗体不是多余的，而是互补的，对于在自然宿主中感染高致病性病毒是必不可少的。
It is believed that CD8(+) T lymphocytes or Abs can independently clear many primary viral infections, including those caused by Orthopoxviruses (OPV), a genus that includes the human pathogens variola and monkeypox and the vaccine species vaccinia virus. However, most experiments addressing the role of Abs and CD8(+) T cells in protection have used viruses that are not specific for the host. In the present study, we used the mouse-specific OPV ectromelia virus and mice deficient in CD40, B cells, or CD8(+) T cells and adoptive transfers of CD8(+) T or B lymphocytes to show that the protection afforded by CD8(+) T cells is incomplete. Despite sustained CD8(+) T cell responses, in the absence of Ab responses ectromelia virus persists. This results in delayed disease and inexorably leads to death. Therefore, CD8(+) T lymphocytes and Abs are not redundant but complementary and essential to survive infections with a highly pathogenic viruses in the natural host.