Opportunities and pitfalls in the quantification of fiber integrity: What can we gain from Q-ball imaging?
Opportunities and pitfalls in the quantification of fiber integrity: What can we gain from Q-ball imaging?
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DOI：
10.1016/j.neuroimage.2010.02.007
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发表时间：
2010-05-15
期刊：
影响因子：
5.7
通讯作者：
Stieltjes, Bram
中科院分区：
文献类型：
--
作者：
Fritzsche, Klaus H.;Laun, Frederik B.;Stieltjes, Bram
纤维完整性的量化是扩散成像临床应用的核心。与弥散张量成像（DTI）相比。Q球成像（QBI）允许描绘体素内的多个纤维方向。然而，该优点尚未被证明直接转化为纤维完整性的上级量化。此外，最近的发展QBI重建与立体角的考虑，导致更尖锐的和内在的归一化取向分布函数。这种技术对量化的影响也是未知的。为了研究这一点，广义分数各向异性（GFA）从原来的和最近的QBI重建方案和DTI派生的分数各向异性（FA）进行了比较评估，使用Monte Carlo模拟和交叉纤维体模的真实的MRI测量。对比噪声比，准确性，独立的采集设置和单纤维各向异性的关系，测量各向异性的交叉进行了评估。在b值约为1000 s/mm（2）的均匀单纤维区域中，FA表现最好。虽然原始QBI重建即使在较高b值和交叉区域中也没有显示出明显的优势，但新的重建方案产生了优越的上级特性，并且推荐用于在较高b值下的量化，特别是在异质纤维配置的区域中。(C)2010年爱思唯尔公司All rights reserved.
The quantification of fiber integrity is central to the clinical application of diffusion imaging. Compared to diffusion tensor imaging (DTI). Q-ball imaging (QBI) allows for the depiction of multiple fiber directions within a voxel. However, this advantage has not yet been shown to translate directly to superior quantification of fiber integrity. Furthermore, recent developments in QBI reconstruction with solid angle consideration have led to sharper and intrinsically normalized orientation distribution functions. The implications of this technique on quantification are also unknown. To investigate this, the generalized fractional anisotropy (GFA) from the original and the more recent QBI reconstruction scheme and the DTI derived fractional anisotropy (FA) were evaluated comparatively using Monte Carlo simulations and real MRI measurements of crossing fiber phantoms. Contrast-to-noise ratio, accuracy, independence of the acquisition setup and the relation of single fiber anisotropies to measured anisotropy in crossings were assessed. In homogeneous single-fiber regions at b-values around 1000 s/mm(2), the FA performed best. While the original QBI reconstruction does not show a clear advantage even at higher b-values and in crossing regions, the new reconstruction scheme yields superior properties and is recommended for quantification at higher b-values and especially in regions of heterogeneous fiber configuration. (C) 2010 Elsevier Inc. All rights reserved.