Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles
Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles
复制标题
DOI：
10.1016/j.febslet.2011.11.022
复制
发表时间：
2012-01
期刊：
影响因子：
3.5
通讯作者：
D. Simón;Esther García-García-Esther-García-García-2060583805;F. Royo;J. Falcón‐Pérez;J. Ávila
中科院分区：
文献类型：
--
作者：
D. Simón;Esther García-García-Esther-García-García-2060583805;F. Royo;J. Falcón‐Pérez;J. Ávila
在非神经元细胞中表达越来越多的tau蛋白。当细胞内量达到阈值水平时，tau蛋白与膜囊泡一起释放到细胞外培养基中。因此，我们提出，tau蛋白可能通过膜囊泡分泌作为细胞机制，以消除过量的tau蛋白，从而避免其毒性。
Increasing amounts of tau protein were expressed in non-neuronal cells. When intracellular amounts reached a threshold level, tau protein was released to the extracellular culture medium in association with membrane vesicles. Hence, we propose that tau might be secreted through membrane vesicles as a cellular mechanism to eliminate the excess of tau protein, thereby avoiding its toxicity.