AUTOREGULATION OF SPINAL-CORD BLOOD-FLOW - IS THE CORD A MICROCOSM OF THE BRAIN
AUTOREGULATION OF SPINAL-CORD BLOOD-FLOW - IS THE CORD A MICROCOSM OF THE BRAIN
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DOI：
10.1161/01.str.17.6.1183
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发表时间：
1986-11-01
期刊：
影响因子：
8.3
通讯作者：
GELINEAU, J
中科院分区：
文献类型：
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作者：
HICKEY, R;ALBIN, MS;GELINEAU, J
在18只连续静脉输注硫喷妥钠麻醉的大鼠中证明了脑和脊髓局部区域的自动调节能力。通过注射放射性微球（Co 57、Sn 113、Ru 103、Sc 46）来测量血流量。在不同水平的平均动脉压（MAP）下进行血流量测量，其中通过新舍尼酮改变MAP以升高MAP或曲美沙芬降低MAP。脊髓的自动调节反映了大脑的自动调节，两种组织的自动调节范围为60至120 mm Hg。在此范围内，脑血流量（CBF）为59.2 ± 0.001。3.2 ml/100 g/min（SEM），脊髓血流量（SCBF）为61.1 ± 0.000ml/100 g/min。3.6.在自动调节范围内，CBF和SCBF无显著差异。在左、右皮质、脑干、丘脑、小脑、海马和颈、胸、腰段脊髓也表现出区域性的自我调节。这些数据为建立巴比妥类麻醉下的自动调节曲线提供了一致的参考点。需要进一步研究其他麻醉剂对脊髓自动调节的影响。脊髓内顺应性可能与颅内顺应性一样，会受到麻醉剂对自身调节作用的不利影响。
The autoregulatory capability of regional areas of the brain and spinal cord was demonstrated in 18 rats anesthetized with a continuous infusion of intravenous pentothal. Blood flow was measured by the injection of radioactive microspheres (Co57, Sn113, Ru103, Sc46). Blood flow measurements were made at varying levels of mean arterial pressure (MAP) which was altered by neosynephrine to raise MAP or trimethaphan to lower MAP. Autoregulation of the spinal cord mirrored that of the brain, with an autoregulatory range of 60 to 120 mm Hg for both tissues. Within this range, cerebral blood flow (CBF) was 59.2 .+-. 3.2 ml/100 g/min (SEM) and spinal cord blood flow (SCBF) was 61.1 .+-. 3.6. There was no significant difference in CBF and SCBF in the autoregulatory range. Autoregulation was also demonstrated regionally in the left cortex, right cortex, brainstem, thalamus, cerebellum, hippocampus and cervical, thoracic and lumbar cord. This data provides a coherent reference point in establishing autoregulatory curves under barbiturate anesthesia. Further investigation of the effects of other anesthetic agents on autoregulation of the spinal cord is needed. It is possible that intraspinal cord compliance, like intracranial compliance, might be adversely affected by the effects of anesthetics on autoregulation.