A new class of murine leukemia virus associated with development of spontaneous lymphomas.
A new class of murine leukemia virus associated with development of spontaneous lymphomas.
复制标题
一类新的鼠白血病病毒与自发性淋巴瘤的发生有关。
DOI：
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发表时间：
1977
影响因子：
11.1
通讯作者：
W. Rowe
中科院分区：
文献类型：
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作者：
J. Hartley;N. K. Wolford;L. Old;W. Rowe
在白血病和晚期白血病前AKR小鼠的胸腺、携带AKR异位病毒诱导位点akv - 1或Akv-2的NIH瑞士小鼠的淋巴瘤以及白血病前C58小鼠的胸腺中检测到一种新型小鼠白血病病毒。这种病毒在水貂肺细胞系中诱导病灶区域的形态改变，暂时被称为“水貂细胞诱导病灶”（MCF）菌株。它们具有异嗜性和n嗜性小鼠白血病病毒的宿主范围，对异嗜性和异嗜性病毒均被抗血清中和，并受到两种病毒的干扰。它们可能代表了一种特殊类型的基因重组，出现在高热带病毒小鼠株的白血病前期，它们可能在自发性淋巴瘤的病因学中起重要作用。
A new type of murine leukemia virus has been detected in thymuses of leukemic and late preleukemic AKR mice, in lymphomas developing in NIH Swiss mice carrying the AKR ectopic virus-inducing loci Akv-I or Akv-2, and in the thymus of a preleukemic C58 mouse. The viruses induce focal areas of morphologic alteration in a mink lung cell line and are tentatively referred to as "mink cell focus-inducing" (MCF) strains. They have the host range of both xenotropic and N-tropic ecotropic murine leukemia viruses, are neutralized by antisera to both ecotropic and xenotropic viruses, and are interfered with by both viruses. They may represent a particular type of genetic recombinant which emerges during the preleukemic period in high-ecotropic-virus mouse strains, and they may play a significant role in the etiology of spontaneous lymphomas.