A lyophilized formulation of RiVax, a recombinant ricin subunit vaccine, retains immunogenicity.
A lyophilized formulation of RiVax, a recombinant ricin subunit vaccine, retains immunogenicity.
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DOI：
10.1016/j.vaccine.2009.12.081
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发表时间：
2010-03-11
期刊：
影响因子：
5.5
通讯作者：
Vitetta, Ellen S.
中科院分区：
文献类型：
--
作者：
Smallshaw, Joan E.;Vitetta, Ellen S.
Ricin is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax) contains two mutations, rendering it non-toxic at high doses. Frozen or alum formulations of RiVax protected mice against ricin administered by injection, gavage or aerosol. Without alum, RiVax was safe and immunogenic in rabbits and human volunteers. For military use, the predominant target group, it would be optimal not to require a cold chain for transport and storage. We have now developed a lyophilized formulation and demonstrated stability and efficacy for at least 1 year stored refrigerated or at room temperature administered with or without alum.
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影响因子：
5.5
作者：
Smallshaw, JE;Richardson, JA;Vitetta, ES
通讯作者：
Vitetta, ES
影响因子：
5.5
作者：
Smallshaw, JE;Firan, A;Vitetta, ES
通讯作者：
Vitetta, ES
影响因子：
3.8
作者：
Maa, YF;Ameri, M;Chen, DX
通讯作者：
Chen, DX
DOI：
10.4161/hv.5.1.6494
发表时间：
2009-01-01
期刊：
HUMAN VACCINES
影响因子：
--
作者：
Chen, Dexiang;Tyagi, Anil;Braun, LaToya Jones
通讯作者：
Braun, LaToya Jones
影响因子：
2.9
作者：
Zhai, SL;Hansen, RK;Slater, NKH
通讯作者：
Slater, NKH