Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice
Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice
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DOI：
10.1016/j.brainresbull.2010.05.011
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发表时间：
2010-08-30
影响因子：
3.8
通讯作者：
Florenco de Sousa, Francisca Clea
中科院分区：
文献类型：
--
作者：
Carlos da Silva, Francisca Charliane;de Oliveira Cito, Maria do Carmo;Florenco de Sousa, Francisca Clea
越来越多的证据表明，嗜离子性谷氨酸n -甲基- d -天冬氨酸受体（NMDA）在包括焦虑和重度抑郁症在内的精神病理病因学中起着重要作用。临床结果表明氯胺酮可用于治疗重度抑郁症。有证据表明，活性氧在许多疾病，特别是神经和精神疾病的发病机制中也起着重要作用。本研究检测了单次给药氯胺酮（5、10和20 mg/kg i.p.）对小鼠行为和氧化应激的改变。氯胺酮在焦虑升高+迷宫模型中表现出显著的焦虑效应，并增加运动活动。在强制游泳和悬尾试验中，观察到氯胺酮给药后静止时间显著减少。除了氯胺酮引起的行为改变外，该药还增加了小鼠前额皮质的脂质过氧化、亚硝酸盐含量和过氧化氢酶活性，同时降低了GSH水平。总之，我们的研究结果证实了氯胺酮的抗抑郁作用，同时也显示了这种药物的促氧化作用。(C) 2010爱思唯尔公司版权所有。
A growing body of evidence has pointed to the ionotropic glutamate N-methyl-D-aspartate receptor (NMDA) as an important player in the etiology of psychopathologies, including anxiety and major depression. Clinical findings suggest that ketamine may be used for the treatment of major depression. There is evidence that reactive oxygen species also play an important role in the pathogenesis of many diseases, particularly those which are neurological and psychiatric in nature. This study examined the behavioral and oxidative stress alterations after a single administration of ketamine (5, 10 and 20 mg/kg i.p.) in mice. Ketamine presented a significant anxiogenic effect in the elevated plus-maze model of anxiety, also increasing locomotor activity. In the forced swimming and tail suspension tests, a significant decrease in immobility time after ketamine administration was observed. In addition to the behavioral changes induced by ketamine, this drug also increased lipid peroxidation, nitrite content and catalase activity, while decreased GSH levels in mice prefrontal cortex. In conclusion, our results confirm the antidepressant effects of ketamine, also showing a pro-oxidant effect of this drug. (C) 2010 Elsevier Inc. All rights reserved.