Environmental enrichment rescues the degraded auditory temporal resolution of cortical neurons induced by early noise exposure
Environmental enrichment rescues the degraded auditory temporal resolution of cortical neurons induced by early noise exposure
复制标题
环境丰富可以挽救早期噪声暴露引起的皮质神经元听觉时间分辨率下降
DOI：
10.1111/ejn.12975
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发表时间：
2015-09-01
影响因子：
3.4
通讯作者：
Zhang, Jiping
中科院分区：
文献类型：
--
作者：
Jiang, Cuiping;Xu, Xiaoxiao;Zhang, Jiping
声音时间信息的准确处理对于人类的语音感知和其他物种特有的交流至关重要。在出生后的发育过程中，听觉皮质表现出依赖环境和经验的可塑性。然而，出生后环境如何影响大脑对声音时间信息的处理还没有完全了解。本研究的目的是确定出生后噪声暴露是否会损害听觉皮质中的神经时间分辨率，如果是的话，环境的丰富是否可以挽救这种退化的神经时间敏锐度。用麻醉大鼠的神经间隙检测阈值作为时间敏锐度的指标，我们发现，幼年大鼠暴露在中等水平的噪声中，成年期的神经间隙检测阈值比成年大鼠暴露在相同的噪声中要高得多。在正常发育的大鼠中，丰富的环境不影响皮质神经间隙检测阈值。然而，在丰富的环境中饲养早期暴露于噪声的大鼠可以促进从噪声引起的神经时间分辨率下降中恢复过来。此外，丰富环境中的音调刺激只对恢复做出了部分贡献。这些结果为噪声引起的听觉皮层神经间隙检测阈值的发育损害提供了证据，并表明环境丰富作为一种非侵入性方法来挽救发育退化的听觉时间加工具有治疗潜力。
The accurate processing of sound temporal information is crucial to human speech perception and other species-specific communication. During postnatal development, the auditory cortex shows environmental and experience-dependent plasticity. However, how the postnatal environment affects cortical processing of sound temporal information is not fully understood. The aim of the present study was to determine whether postnatal noise exposure impairs neural temporal resolution in the auditory cortex, and, if so, whether environmental enrichment can rescue this degraded neural temporal acuity. Using the neural gap detection threshold determined in anesthetized rats as an index of temporal acuity, we found that exposure of juvenile rats to moderate-level noise induced much higher neural gap detection thresholds in adulthood than exposure of adult rats to the same noise. Environmental enrichment did not affect cortical neural gap detection thresholds in normally developing rats. However, rearing of rats with early noise exposure in an enriched environment promoted recovery from the noise-induced degraded neural temporal resolution. In addition, the tonal stimuli in the enriched environment contributed to only a portion of the recovery. These results provide evidence for noise-induced developmental impairment in neural gap detection thresholds in the auditory cortex, and suggest a therapeutic potential for environmental enrichment as a non-invasive approach to rescue developmentally degraded auditory temporal processing.