Use of oral antidiabetic drugs in Japanese working-age patients with type 2 diabetes mellitus: dosing pattern for metformin initiators
Use of oral antidiabetic drugs in Japanese working-age patients with type 2 diabetes mellitus: dosing pattern for metformin initiators
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DOI：
10.1080/03007995.2020.1729710
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发表时间：
2020-02-26
影响因子：
2.3
通讯作者：
Miyata, Hiroaki
中科院分区：
文献类型：
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作者：
Kameda, Toshiki;Kumamaru, Hiraku;Miyata, Hiroaki
目的：确定日本工作人群中2型糖尿病（T2 DM）患者的降糖药物使用模式，特别关注二甲双胍剂量。方法：我们使用了一个行政索赔数据库链接到大型企业的年度健康检查数据。收集了2014年至2017年期间开始使用降糖药物的T2 DM患者的数据（n = 20，401）。我们评估了使用的抗糖尿病药物的类型和使用每种药物的患者的特征。在二甲双胍使用者中，我们评估了在开始后12个月内以3个月为间隔的剂量或治疗的滴定。结果如下：在20，401名新的抗糖尿病药物使用者中，研究期间最常使用的药物是二肽基肽酶-4抑制剂（DPP 4 is; 47.4%），其次是双胍类（18.5%）和钠葡萄糖协同转运蛋白-2抑制剂（SGLT 2 is; 6.7%）。大多数开始使用二甲双胍的患者每日处方剂量为500 mg或更少（72.9%）;仅2.0%的患者每日处方剂量>1000 mg。此外，27%的患者在1年随访期间保持相同的每日剂量，而另外29.9%的患者完全停止了抗糖尿病治疗。结论：在日本T2 DM患者中观察到一种独特的处方模式，DPP 4 is而非二甲双胍主要用作一线治疗。SGLT 2的处方频率较低。二甲双胍的日剂量为
Objective: To determine the pattern of antidiabetic drug use, with a particular focus on the metformin dose, among patients with type 2 diabetes mellitus (T2DM) in a Japanese working population. Methods: We used an administrative claims database linked to yearly health check-up data from large corporations. Data were collected for T2DM patients who began using an antidiabetic drug between 2014 and 2017 (n = 20,401). We evaluated the type of antidiabetic drug used and the characteristics of the patients using each type of drug. Among the metformin users, we assessed the titration in its dose or treatment during the 12 month period after initiation at 3 month intervals. Results: Among 20,401 new antidiabetic users, the most frequently used agents during the study period were dipeptidyl peptidase-4 inhibitors (DPP4is; 47.4%), followed by biguanides (18.5%) and sodium glucose cotransporter-2 inhibitors (SGLT2is; 6.7%). Most patients who initiated with metformin were prescribed 500 mg or less daily (72.9%); only 2.0% were prescribed a daily dose of >1000 mg. Moreover, 27% remained on the same daily dose during the 1 year follow-up, whereas another 29.9% discontinued their antidiabetic treatment altogether. Conclusions: A unique pattern of prescription was observed amongst Japanese patients with T2DM, and DPP4is, rather than metformin, were predominantly used as the first-line treatment. SGLT2is were infrequently prescribed. Metformin was prescribed at a daily dose of