Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus
Comparison of the effect of multiple short-duration with single long-duration exercise sessions on glucose homeostasis in type 2 diabetes mellitus
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DOI：
10.1007/s00125-007-0783-0
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发表时间：
2007-11-01
期刊：
影响因子：
8.2
通讯作者：
Dela, F.
中科院分区：
文献类型：
--
作者：
Eriksen, L.;Dahl-Petersen, I.;Dela, F.
目的/假设我们评估和比较两种不同的运动方案在老年男性2型糖尿病mellitus. Methods血糖控制的影响，18例2型糖尿病患者进行了为期5周的家庭自行车训练。患者被随机分配到两个训练计划之一，最大摄氧量为60%：每天三次10分钟的训练（3 x 10）或每天一次30分钟的训练（1 x 30）。在3小时口服葡萄糖耐量试验（OGTT）期间测定血浆胰岛素、C肽和葡萄糖浓度。胰岛素敏感性指数（ISIcomposite），肝前胰岛素分泌率（ISR）和每单位葡萄糖浓度变化（B-总）的胰岛素分泌变化进行了计算。在3 × 10（n=9）组中，空腹血糖（p=0.01）、120 min葡萄糖OGTT（p=0.04）以及120 min（p < 0.04）和180 min（p=0.07）的血糖浓度曲线下面积降低。这些参数在组1 x 30（n=9）中保持不变。两个运动组的ISIcomposite、ISR和Btotal均无显著变化。在一个匹配的时间控制组（n=10），贫血控制并没有改变。结论/解释中度到高强度的训练进行3 × 10分钟/天是最好的1 × 30分钟/天关于贫血控制的影响。这是尽管事实上，心肺健康增加了类似的两个运动组。一个可能的解释是，与多个短的日常会话相关的能量消耗可能大于单个日常会话。
Aims/hypothesis We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus.Methods Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two training programmes at 60% of maximal oxygen uptake: three 10 min sessions per day (3 x 10) or one 30 min session per day (1 x 30). Plasma insulin, C-peptide and glucose concentrations were measured during a 3 h oral glucose tolerance test (OGTT). Insulin sensitivity index (ISIcomposite), pre-hepatic insulin secretion rates (ISR) and change in insulin secretion per unit change in glucose concentrations (B-total) were calculated.Results Cardiorespiratory fitness increased in response to training in both groups. In group 3 x 10 (n=9) fasting plasma glucose (p=0.01), 120 min glucose OGTT (p=0.04) and plasma glucose concentration areas under the curve at 120 min (p < 0.04) and 180 min (p=0.07) decreased. These parameters remained unchanged in group 1 x 30 (n=9). No significant changes were found in ISIcomposite, ISR and Btotal in either of the exercise groups. In a matched time- control group (n=10), glycaemic control did not change.Conclusions/interpretation Moderate to high-intensity training performed at 3 x 10 min/day is preferable to 1 x 30 min/day with regard to effects on glycaemic control. This is in spite of the fact that cardiorespiratory fitness increased similarly in both exercise groups. A possible explanation is that the energy expenditure associated with multiple short daily sessions may be greater than that in a single daily session.