Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer.
Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer.
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DOI：
10.1007/s00018-009-9153-z
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发表时间：
2009-06
影响因子：
8
通讯作者：
Seldin, D. C.
中科院分区：
文献类型：
--
作者：
Dominguez, I.;Sonenshein, G. E.;Seldin, D. C.
关键词：
CK 2是存在于所有真核生物中的高度保守的四聚体丝氨酸/苏氨酸激酶。它是组成型活性的，并且似乎受到表达和活性水平以及亚细胞定位的调节。反过来，它已被假定为控制许多蛋白质的功能，通过影响蛋白质的稳定性，蛋白质相互作用和亚细胞定位的磷酸化的变化。通过这些机制，CK 2调节许多基本的细胞特性。一种具有这种主要调节功能的酶可能在器官发育和癌症中很重要。我们已经表明，CK 2催化亚基的过度表达能够促进肿瘤的发生，并且在发育过程中CK 2催化亚基的丢失可能是致命的。通过在细胞、小鼠和青蛙中的研究，我们和其他人已经确定Wnt和NF-κB通路是在胚胎发育和癌症中受CK 2活性调节的两个关键信号转导通路。这些结果表明，抑制CK 2可能有助于治疗癌症，但对发育中的生物体有危险。(Part多作者评论）
CK2 is a highly conserved tetrameric serine/threonine kinase present in all eukaryotic organisms. It is constitutively active, and appears to be regulated by level of expression and activity, and subcellular localization. In turn, it has been postulated to control the function of many proteins through changes in phosphorylation that affect protein stability, proteinprotein interactions, and subcellular localization. Through these mechanisms, CK2 regulates many fundamental cellular properties. An enzyme that carries out such a master regulatory function is likely to be important in organismic development and in cancer. We have shown that overexpression of CK2 catalytic subunits is capable of promoting tumorigenesis, and that loss of CK2 catalytic subunits in development can be lethal. Through studies in cells, mice, and frogs, we and others have identified the Wnt and NF-κB pathways as two key signal transduction pathways that are regulated by CK2 activity, in embryonic development and in cancer. These results suggest that inhibiting CK2 could be useful in treating cancer, but dangerous to developing organisms. (Part of a Multi-author Review)
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作者：
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通讯作者：
Boldyreff, B
DOI：
10.1152/ajpgi.00359.2006
发表时间：
2007-06-01
影响因子：
4.5
作者：
Apte, Udayan;Zeng, Gang;Monga, Satdarshan P. S.
通讯作者：
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