Modeling autism spectrum disorders with human neurons.
Modeling autism spectrum disorders with human neurons.
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DOI：
10.1016/j.brainres.2016.01.057
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发表时间：
2017-02-01
期刊：
影响因子：
2.9
通讯作者：
Muotri AR
中科院分区：
文献类型：
--
作者：
Beltrão-Braga PC;Muotri AR
自闭症谱系障碍（ASD）是一组神经发育障碍，其特征是社会沟通和互动受损以及限制和重复行为。虽然ASD被怀疑具有遗传性或散发性遗传基础，但其潜在的病因和发病机制尚不清楚。因此，使用诱导多能干细胞（iPSC）重新编程来自ASD患者的细胞产生的活的人类神经元和神经胶质细胞为阐明这些疾病的病理生理学提供了前所未有的机会，提供了关于ASD的新见解以及开发和测试治疗化合物的潜在平台。在这里，我们讨论了ASD建模的最新技术，包括这项技术的局限性，以及潜在的未来发展方向。
Autism Spectrum Disorder (ASD) is a group of neurodevelopmental disorders characterized by impaired social communication and interactions and by restricted and repetitive behaviors. Although ASD is suspected to have a heritable or sporadic genetic basis, its underlying etiology and pathogenesis are not well understood. Therefore, viable human neurons and glial cells produced using induced pluripotent stem cells (iPSC) to reprogram cells from individuals affected with ASD provide an unprecedented opportunity to elucidate the pathophysiology of these disorders, providing novel insights regarding ASD and a potential platform to develop and test therapeutic compounds. Herein, we discuss the state of art with regards to ASD modeling, including limitations of this technology, as well as potential future directions.