Luria-Delbrück, revisited: the classic experiment does not rule out Lamarckian evolution.
Luria-Delbrück, revisited: the classic experiment does not rule out Lamarckian evolution.
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卢里亚-德尔布吕克，重温：经典实验并不排除拉马克进化论。
DOI：
10.1088/1478-3975/aa8230
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发表时间：
2017
期刊：
影响因子：
2
通讯作者：
Nemenman,Ilya
中科院分区：
文献类型：
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作者：
Holmes,CarolineM;Ghafari,Mahan;Abbas,Anzar;Saravanan,Varun;Nemenman,Ilya
我们重新检查了经典的Luria-Delbrück涨落实验的数据，该实验通常被认为是建立了进化论的达尔文基础。我们认为，为了让实验排除拉马克进化模型，实验必须支持纯粹的达尔文进化，而不是拉马克模型和同时允许达尔文和拉马克机制的模型(就像具有CRISPR-Cas免疫力的细菌所发生的那样)。1943年的原始论文中没有对组合模型进行分析。Luria-Delbrück的论文也没有考虑两个模型都不适合实验的可能性。使用贝叶斯模型选择，我们发现Luria-Delbrück实验确实支持达尔文进化论而不是纯粹的拉马克进化论。然而，我们的分析并不排除组合模型，因此也不能排除拉马克对进化动力学的贡献。
We re-examined data from the classic Luria–Delbrück fluctuation experiment, which is often credited with establishing a Darwinian basis for evolution. We argue that, for the Lamarckian model of evolution to be ruled out by the experiment, the experiment must favor pure Darwinian evolution over both the Lamarckian model and a model that allows both Darwinian and Lamarckian mechanisms (as would happen for bacteria with CRISPR-Cas immunity). Analysis of the combined model was not performed in the original 1943 paper. The Luria–Delbrück paper also did not consider the possibility of neither model fitting the experiment. Using Bayesian model selection, we find that the Luria–Delbrück experiment, indeed, favors the Darwinian evolution over purely Lamarckian. However, our analysis does not rule out the combined model, and hence cannot rule out Lamarckian contributions to the evolutionary dynamics.