Satisfaction With Clinician-Led Germline Genetic Counseling in Patients With Prostate Cancer.
Satisfaction With Clinician-Led Germline Genetic Counseling in Patients With Prostate Cancer.
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DOI：
10.1097/ju.0000000000002865
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发表时间：
2022-11
影响因子：
6.6
通讯作者：
Morgan, Todd M. M.
中科院分区：
文献类型：
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作者：
Abusamra, Sophia M. M.;Solorzano, Marissa A. A.;Luke, Mallory;Quarles, Jake;Jacobs, Michelle F. F.;Das, Sanjay;Kasputis, Amy;Okoth, Linda A. A.;Patel, Milan;Seymore, Mariana;Caram, Megan E. V.;Dunn, Rodney L. L.;Merajver, Sofia D. D.;Stoffel, Elena M. M.;Reichert, Zachery R. R.;Morgan, Todd M. M.
前列腺癌患者生殖系检测的适应症在过去十年中大幅扩大。随着遗传咨询师近乎普遍的短缺和需求的增加，增加获得遗传咨询的机会至关重要。我们试图前瞻性地实施和评估临床医生主导的遗传咨询和检测方法。符合NCCN基因测试标准的转移性或局部性前列腺癌患者，他们的泌尿科医生或内科肿瘤学家为他们提供测试前的遗传咨询，作为他们常规临床护理的一部分，同时与他们接洽，以参加“前列腺癌研究中的生殖系遗传学”。征得同意的患者使用经过验证的工具填写咨询后调查，以评估咨询的质量。对于选择接受基因检测的患者，在结果公布后，还完成了一份额外的有效问卷。主要结果是接受检测的男性比例，目标是60%的患者。第二个结果是对咨询的总体满意度，目标是85%的患者。275名患者入选，203名患者被选接受基因检测。咨询后调查来自265名患者，基因检测后调查来自132名患者。患者满意度很高，98%的患者报告对检测前咨询的整体质量感到满意，74%的患者选择接受基因检测。这些结果支持了临床医生主导的遗传咨询在前列腺癌中的有效性。通过临床医生培训，这种方法可以用来扩大适当的种系基因检测的机会。在这项研究中，我们实施了一种由临床医生主导的遗传咨询和检测方法。我们发现，这种基因检测方法是有效的，可以用来扩大基因检测的渠道。
Indications for germline testing in prostate cancer patients have expanded substantially over the past decade. With a near-universal shortage of genetic counselors and increasing demand, increased access to genetic counseling is crucial. We sought to prospectively implement and assess a clinician-led approach to genetic counseling and testing. Men with metastatic or localized prostate cancer meeting NCCN criteria for consideration of genetic testing were offered pre-test genetic counseling by their urologist or medical oncologist as part of their routine clinical care and concurrently approached for enrollment in the “Germline Genetics in Prostate Cancer Study.” Consented patients filled out a post-counseling survey using validated instruments to assess the quality of counseling. For patients who elected to undergo genetic testing, an additional validated questionnaire was completed following disclosure of results. The primary outcome was the proportion of men undergoing testing, with a target >60% of patients. The secondary outcome was overall satisfaction with counseling, with a target >85% of patients. 275 patients enrolled, and 203 patients elected to undergo genetic testing. Post-counseling surveys were obtained from 265 patients, and post-genetic testing surveys were obtained from 132 patients. Patient satisfaction was high, with 98% of patients reporting being satisfied with the overall quality of pre-test counseling, and 74% of patients elected to undergo genetic testing. These results support the effectiveness of clinician-led genetic counseling in prostate cancer. With clinician training, this approach can be utilized to expand access to appropriate germline genetic testing. In this study, we implemented a clinician-led approach to genetic counseling and testing. We found that this approach to genetic testing is effective and can be used to expand access to genetic testing.
影响因子：
1.2
作者：
Jordan SE;Spring S;Kamath P;Schlumbrecht MP;Matthew Pearson J;Sinno AK;George SHL;Huang M
通讯作者：
Huang M