The inferior olivary nucleus: A postmortem study of essential tremor cases versus controls
The inferior olivary nucleus: A postmortem study of essential tremor cases versus controls
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DOI：
10.1002/mds.25400
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发表时间：
2013-06-01
影响因子：
8.6
通讯作者：
Faust, Phyllis L.
中科院分区：
文献类型：
--
作者：
Louis, Elan D.;Babij, Rachel;Faust, Phyllis L.
特发性震颤的发病机制尚不清楚。历史上，人们假设下橄榄核在特发性震颤的震颤产生中起着重要作用，但对该大脑区域的详细、受控、解剖病理研究尚未进行。在特发性震颤集中脑存储库，对14例特发性震颤病例和15例年龄匹配的对照进行了详细的尸检研究，观察下橄榄核的微观变化。采用一系列指标量化下橄榄核及其输入和输出束的微观神经元和胶质的变化。橄榄树线性神经元密度也被评估。病例和对照组在任何评估指标方面都没有差异（P值范围为0.23至1.0）。病例与对照组橄榄线性神经元密度相似（P=0.62）。桨状神经元是橄榄神经元的一种形态变化，据我们所知，以前没有发现过，但在特发性震颤病例和对照组中发生的程度相同（P=0.89），并与神经元丢失和胶质瘤的几种标志物相关。系统的死后研究下橄榄核的微观变化没有发现病例和对照组之间的任何差异。这些数据，以及正电子发射断层扫描数据，都未能识别出橄榄的任何代谢异常，这表明，如果橄榄与特发性震颤有关，那么就没有明确可识别的结构或代谢相关。(c) 2013年运动障碍协会
The pathogenesis of essential tremor is poorly understood. Historically, it has been hypothesized that the inferior olivary nucleus plays an important role in the generation of tremor in essential tremor, yet a detailed, controlled, anatomic-pathological study of that brain region has yet to be conducted. A detailed postmortem study was undertaken of the microscopic changes in the inferior olivary nucleus of 14 essential tremor cases versus 15 age-matched controls at the Essential Tremor Centralized Brain Repository. A series of metrics was used to quantify microscopic neuronal and glial changes in the inferior olivary nucleus and its input and output tracts. Olivary linear neuronal density also was assessed. Cases and controls did not differ from one another with respect to any of the assessed metrics (P values ranged from 0.23 to 1.0). Olivary linear neuronal density also was similar in cases and controls (P=0.62). Paddle-shaped neurons, a morphologic shape change in olivary neurons, which, to our knowledge, have not been previously recognized, occurred to an equal degree in essential tremor cases and controls (P=0.89) and were correlated with several markers of neuronal loss and gliosis. A systematic postmortem study of the microscopic changes in the inferior olivary nucleus did not detect any differences between cases and controls. These data, along with positron emission tomography data, which have failed to identify any metabolic abnormality of the olive, indicate that, if the olive is involved in essential tremor, then there is no clearly identifiable structural or metabolic correlate. (c) 2013 Movement Disorder Society