Spatial and Temporal Aspects of Signalling
Spatial and Temporal Aspects of Signalling
复制标题
信号传输的空间和时间方面
DOI：
--
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
M. Berridge
中科院分区：
文献类型：
--
作者：
M. Berridge
细胞信号通路的功能和效率非常依赖于它们在空间和时间上的组织。就空间组织而言，信号组件在细胞位置以及它们如何将信息从细胞的一个区域传递到另一个区域方面是高度组织的。这种信号通路的空间组织依赖于使用信号转导结构域构建信号通路的信号组分之间发生的分子相互作用。通常，负责信息传递机制的成分通过附着在支架蛋白上形成大分子信号复合物而保持在适当位置。有时，这些大分子复合物可以通过定位于细胞的特定区域而进一步组织，如在脂筏和小泡中或在骨骼和心脏细胞的t小管区域中发现。
The function and efficiency of cell signalling pathways are very dependent on their organization both in space and time. With regard to spatial organization, signalling components are highly organized with respect to their cellular location and how they transmit information from one region of the cell to another. This spatial organization of signalling pathways depends on the molecular interactions that occur between signalling components that use signal transduction domains to construct signalling pathways. Very often, the components responsible for information transfer mechanisms are held in place by being attached to scaffolding proteins to form macromolecular signalling complexes. Sometimes these macromolecular complexes can be organized further by being localized to specific regions of the cell, as found in lipid rafts and caveolae or in the T-tubule regions of skeletal and cardiac cells.
DOI：
10.1152/ajprenal.00425.2005
发表时间：
2006-08-01
影响因子：
4.2
作者：
Peti-Peterdi, Janos
通讯作者：
Peti-Peterdi, Janos