THE VALUE OF COMPLEMENT AND IMMUNE-COMPLEX DETERMINATIONS IN MONITORING DISEASE-ACTIVITY IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
THE VALUE OF COMPLEMENT AND IMMUNE-COMPLEX DETERMINATIONS IN MONITORING DISEASE-ACTIVITY IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1002/art.1780280810
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发表时间：
1985-01-01
影响因子：
--
通讯作者：
VANES, LA
中科院分区：
文献类型：
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作者：
VALENTIJN, RM;VANOVERHAGEN, H;VANES, LA
对33例系统性红斑狼疮患者的系列血清进行了CH50、C3、补体第三组分、补体第四组分及循环免疫复合物的检测。用5种不同的方法测定循环免疫复合体。疾病活跃度由评分系统确定。在一项患者间分析中，总体疾病活动性与CH50、C3水平以及[补体成分]C1q结合试验阳性结果显著相关。除了C3水平降低外，所有血清学试验的敏感性、特异性和预测值都很低。患者内部分析显示，33名患者中有11名患者有特定的活动参数。这些血清学试验在评估系统性红斑狼疮患者的疾病活动性方面并不可靠，尽管一小部分患者会表现出特定于患者的活动性参数。
Serial serum samples from 33 patients with systemic lupus erythematosus were tested for CH50 [total hemolytic complement], C3, [3rd component of complement], C4 [4th component of complement] and circulating immune complexes. Circulating immune complexes were determined by 5 different assays. Disease activity was determined by a scoring system. On an interpatient analysis, overall disease activity correlated significantly with levels of CH50, C3 and a positive result on [complement component] C1q binding assay. With the exception of depressed C3 levels, the sensitivity, specificity and predictive values of all the serologic tests were low. An intrapatient analysis revealed a patient-specific activity parameter in 11 of the 33 patients. These serologic tests are not reliable in assessing disease activity in patients with systemic lupus erythematosus, although a small subgroup of patients will exhibit a patient-specific activity parameter.