In vivo SPECT imaging of vesicular acetylcholine transporter using [123I]-IBVM in early Alzheimer's disease
In vivo SPECT imaging of vesicular acetylcholine transporter using [123I]-IBVM in early Alzheimer's disease
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DOI：
10.1016/j.neuroimage.2007.11.028
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发表时间：
2008-03-01
期刊：
影响因子：
5.7
通讯作者：
Allard, M.
中科院分区：
文献类型：
--
作者：
Mazere, J.;Prunier, C.;Allard, M.
简介：人们对阿尔茨海默病早期阶段的胆碱能活性知之甚少。我们使用 [I-123]-碘苯并维沙米考 ([I-123]-IBVM) 和单光子计算机断层扫描 (SPECT)，研究了早期 AD 和年龄匹配对照中囊泡乙酰胆碱转运蛋白分布的差异。材料和方法：16 名受试者（8 名对照，8 名 AD）接受了 [I-123]-IBVM SPECT 扫描、磁性 T1 加权解剖扫描共振 (MR) 成像和简易精神状态评估 (MMSE)。使用统计参数映射 (SPM 02) 进行图像分析。涉及将每张 SPECT 图像与 MR 扫描进行配准，然后对蒙特利尔神经学研究所标准大脑进行空间归一化，并对每张 SPECT 图像进行平滑处理。分别使用两个样本 t 检验和线性回归评估组效应和相关性。使用两个样本 t 检验，通过每次 MR 扫描的基于体素的形态测量来评估两组之间的萎缩差异。结果：AD 和对照组之间的 MMSE 值显着不同。相对于对照组，AD 受试者扣带皮层和海马旁杏仁复合体中的 [I-123]-IBVM 结合显着降低 (47-62%)。这些模式似乎与萎缩区域无关。结论：这些结果强烈表明胆碱能变性发生在 AD 早期，并且可能与认知功能损害有关。这里使用的胆碱能神经元成像可以有效识别潜在的胆碱能治疗反应者。 (c) 2007 Elsevier Inc. 保留所有权利。
Introduction: Little is known about cholinergic activity in the early stage of Alzheimer's disease. We investigated differences in the distribution of vesicular acetylcholine transporter, using [I-123]-iodobenzovesamicol ([I-123]-IBVM) and Single Photon Computed Tomography (SPECT), in early AD and age-matched controls.Materials and methods: Sixteen subjects (8 controls, 8 AD) underwent [I-123]-IBVM SPECT scanning, T1-weighted anatomic scan by Magnetic Resonance (MR) imaging and Mini-Mental State Evaluation (MMSE). Image analysis, using Statistical Parametric Mapping (SPM 02). involved coregistration of each SPECT image to the MR scan, followed by a spatial normalisation to the Montreal Neurological Institute standard brain and a smoothing of each SPECT image. Group effects and correlation were assessed using two sample t-tests and linear regression respectively. Atrophy difference between the two groups was assessed by voxel-based morphometry of each MR scan using two sample t-tests.Results: MMSE values were significantly different between AD and controls. Relative to controls, a significant decrease in [I-123]-IBVM binding (47-62%) was apparent in AD subjects in cingulate cortex and parahippocampal-amygdaloid complex. These patterns appeared to be independent of atrophied areas.Conclusion: These results strongly suggest that a cholinergic degeneration occurs in the early stage of AD and could be involved in the impairment of the cognitive functions. Imaging of cholinergic neurons used here could be effective in identifying potential cholinergic treatment responders. (c) 2007 Elsevier Inc. All rights reserved.