Changes in Branched-Chain Amino Acids One Year after Sleeve Gastrectomy in Youth with Obesity and Their Association with Changes in Insulin Resistance.
Changes in Branched-Chain Amino Acids One Year after Sleeve Gastrectomy in Youth with Obesity and Their Association with Changes in Insulin Resistance.
复制标题
青少年肥胖患者袖式胃切除术后1年支链氨基酸的变化及其与胰岛素抵抗变化的关系
DOI：
10.3390/nu15173801
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发表时间：
2023-08-30
期刊：
影响因子：
5.9
通讯作者：
Singhal, Vibha
中科院分区：
文献类型：
--
作者：
Becetti, Imen;Lauze, Meghan;Lee, Hang;Bredella, Miriam A.;Misra, Madhusmita;Singhal, Vibha
关键词：
肥胖成人在代谢和减肥手术(MBS)后支链氨基酸(BCAA)水平降低，这被认为有助于MBS的代谢优势。我们调查了62名13-24岁的重度肥胖者(47名女性)超过12个月的这种关系。30例行袖状胃切除术(SG)，32例行非手术对照(NS)。在进行混合餐耐量试验后，我们测量了空腹胰岛素、血糖、糖化血红蛋白(HbA1c)、异亮氨酸、亮氨酸和缬氨酸浓度，以及餐后胰岛素和血糖。收集了24小时的食品召回记录。在基线时，各组在支链氨基酸、HbA1C、HOMA-IR、松田指数、胰岛素生成指数或口腔倾向指数(ODI)的摄入量或血清水平上没有差异。在12个月中，与NS组相比，SG组血清BCAA的降幅更大，并且SG组的BCAA摄入量显著减少。与NS组相比，SG组的HbA1c和HOMA-IR下降幅度更大，松田指数和ODI升高。在SG组，基线亮氨酸和总支链氨基酸浓度与基线松田指数呈负相关。血清亮氨酸的降低与12个月后HOMA-IR的降低呈正相关。这些关联表明支链氨基酸在调节代谢健康方面具有潜在的作用。减少饮食摄入量和血清支链氨基酸浓度可能会降低胰岛素抵抗。
Adults with obesity have a reduction in branched-chain amino acid (BCAA) levels following metabolic and bariatric surgery (MBS), which is hypothesized to contribute to the metabolic advantages of MBS. We examined this relationship in 62 youth 13–24 years old with severe obesity (47 female) over 12 months. Thirty had sleeve gastrectomy (SG) and 32 were non-surgical controls (NS). We measured fasting insulin, glucose, glycated hemoglobin (HbA1c), isoleucine, leucine, and valine concentrations, and post-prandial insulin and glucose, following a mixed meal tolerance test. Twenty-four-hour food recalls were collected. At baseline, groups did not differ in the intake or the serum levels of BCAAs, HbA1C, HOMA-IR, Matsuda index, insulinogenic index, or oral Disposition index (oDI). Over 12 months, SG vs. NS had greater reductions in serum BCAAs, and SG had significant reductions in BCAA intake. SG vs. NS had greater reductions in HbA1c and HOMA-IR, with increases in the Matsuda index and oDI. In SG, baseline leucine and total BCAA concentrations were negatively correlated with the baseline Matsuda index. Reductions in serum leucine were positively associated with the reductions in HOMA-IR over 12 months. These associations suggest a potential role of BCAA in regulating metabolic health. Reducing dietary intake and serum BCAA concentrations may reduce insulin resistance.
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DOI：
10.1056/nejmoa1506699
发表时间：
2016-01-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inge TH;Courcoulas AP;Jenkins TM;Michalsky MP;Helmrath MA;Brandt ML;Harmon CM;Zeller MH;Chen MK;Xanthakos SA;Horlick M;Buncher CR;Teen-LABS Consortium
通讯作者：
Teen-LABS Consortium
影响因子：
4.6
作者：
Hernández-Alvarez MI;Díaz-Ramos A;Berdasco M;Cobb J;Planet E;Cooper D;Pazderska A;Wanic K;O'Hanlon D;Gomez A;de la Ballina LR;Esteller M;Palacin M;O'Gorman DJ;Nolan JJ;Zorzano A
通讯作者：
Zorzano A
影响因子：
8.1
作者：
Lerin C;Goldfine AB;Boes T;Liu M;Kasif S;Dreyfuss JM;De Sousa-Coelho AL;Daher G;Manoli I;Sysol JR;Isganaitis E;Jessen N;Goodyear LJ;Beebe K;Gall W;Venditti CP;Patti ME
通讯作者：
Patti ME
DOI：
10.1152/ajpendo.00630.2012
发表时间：
2013-06-01
影响因子：
5.1
作者：
Lackey, Denise E.;Lynch, Christopher J.;Adams, Sean H.
通讯作者：
Adams, Sean H.
影响因子：
120.7
作者：
Lawrence, Jean M.;Divers, Jasmin;Liese, Angela D.
通讯作者：
Liese, Angela D.