MOLECULAR-BASIS OF BLUETONGUE VIRUS NEUTRALIZATION
MOLECULAR-BASIS OF BLUETONGUE VIRUS NEUTRALIZATION
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DOI：
10.1128/jvi.48.3.627-632.1983
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发表时间：
1983-01-01
影响因子：
5.4
通讯作者：
ROY, P
中科院分区：
文献类型：
--
作者：
KAHLON, J;SUGIYAMA, K;ROY, P
对蓝舌病病毒血清型10和11及其型间复制株的分子和血清学分析表明，病毒RNA片段L2编码蓝舌病病毒型特异性抗原。通过寡核苷酸指纹分析对亲本和抗性病毒的单个RNA片段进行表征。通过克利夫兰肽图分析其病毒粒子多肽表明，L2基因与病毒P2蛋白共线性分离，暗示其为负责病毒血清型特异性的抗原。
Molecular and serological analyses of bluetongue virus serotypes 10 and 11 and their intertype reassortants indicate that the viral RNA segment L2 codes for the serotype-specific antigen. Individual RNA segments of parental and reassortant viruses were characterized by oligonucleotide fingerprint analyses. Analyses of their virion polypeptides by Cleveland peptide mapping demonstrated that the L2 gene segregated colinearly with the viral P2 protein, implicating it as the antigen that is responsible for the viral serotype specificity.