Orthostatic hypotension and the incidence of coronary heart disease: The atherosclerosis risk in communities study
Orthostatic hypotension and the incidence of coronary heart disease: The atherosclerosis risk in communities study
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DOI：
10.1016/s0895-7061(99)00257-5
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发表时间：
2000-06-01
影响因子：
3.2
通讯作者：
Szklo, M
中科院分区：
文献类型：
--
作者：
Rose, KM;Tyroler, HA;Szklo, M
我们在12,433名参加社区动脉粥样硬化风险（ARIC）研究的黑人和白色中年男性和女性中，研究了基线检查（1987-1989）时体位性低血压（OH）与平均6年内冠心病（CHD）发病率之间的关系。OH定义为从仰卧位变为站立位后SEP降低大于或等于20 mm Hg或DBP降低大于或等于10 mm Hg。CHD事件包括明确或很可能的心肌梗死（MI）、无症状MI和致死性CHD。5%的参与者患有OH。患病率随着年龄的增长而增加，在有心血管疾病（CVD）相关合并症和危险因素的人群中更常见。OH患者CHD风险增加（风险比[HR] = 3.49，95%置信区间[CI] = 2.58，4.73）。在控制年龄、种族、性别、共病和CVD风险因素后，这种关联减弱（HR = 1.85，95% CI = 1.31，2.63）。美国高血压杂志2000;13：571-578（C）2000年美国高血压杂志，有限公司。
We examined the association between orthostatic hypotension (OH) at baseline examination (1987-1989) and the incidence of coronary heart disease (CHD) over an average of 6 years, among 12,433 black and white middle-aged men and women participating in the Atherosclerosis Risk in Communities (ARIC) study. OH was defined as a SEP decrease greater than or equal to 20 mm Hg or a DBP decrease greater than or equal to 10 mm Hg after changing from supine to standing. CHD events included definite or probable myocardial infarctions (MI), silent MI, and fatal CHD. Five percent of participants had OH. Prevalence increased with advancing age and was more common among those with cardiovascular disease (CVD)-related comorbidities and risk factors. Those with OH had an increased risk of CHD (hazard ratio [HR] = 3.49, 95% confidence interval [CI] = 2.58, 4.73). This association was attenuated after controlling for age, ethnicity, gender, comorbid conditions, and CVD risk factors (HR = 1.85, 95% CI = 1.31, 2.63). Am J Hypertens 2000;13:571-578 (C) 2000 American Journal of Hypertension, Ltd.