Atrial fibrillation is associated with different levels of physical activity levels at different ages in men
Atrial fibrillation is associated with different levels of physical activity levels at different ages in men
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DOI：
10.1136/heartjnl-2013-305304
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发表时间：
2014-07-01
期刊：
影响因子：
5.7
通讯作者：
Larsson, Susanna C.
中科院分区：
文献类型：
--
作者：
Drca, Nikola;Wolk, Alicja;Larsson, Susanna C.
目的本研究探讨在不同年龄和不同类型的体力活动的影响，在一个大的队列中的瑞典男性房颤（AF）的风险。方法有关体力活动的信息是从44 410 AF自由的男性，年龄45-79岁（平均年龄=60），谁完成了自填问卷在1997年的基线。参与者回顾性报告了他们一生中（15岁、30岁和50岁时，以及基线时（平均年龄=60岁））用于休闲运动和步行或骑自行车的时间。参与者在瑞典国家住院患者登记处进行随访，以确定AF。考克斯比例风险回归模型被用来估计相对风险（RR）与95%CI，调整潜在的confounders.Results在一个中位数为12年的随访期间，4568例AF被诊断。我们观察到RR为1.19（95% CI 1.05至1.36）在30岁时每周运动>5小时的男性中发生AF，与30岁时每周运动5小时相比，（1小时/天vs几乎从不），排除基线时有冠心病或心力衰竭病史的男性后，结论年轻时休闲时间锻炼与AF风险增加相关，而老年时步行/骑自行车与AF风险降低相关。
Objective This study examines the influence of physical activity at different ages and of different types, on the risk of developing atrial fibrillation (AF) in a large cohort of Swedish men.Methods Information about physical activity was obtained from 44 410 AF-free men, aged 45-79 years (mean age=60), who had completed a self-administered questionnaire at baseline in 1997. Participants reported retrospectively their time spent on leisure-time exercise and on walking or bicycling throughout their lifetime (at 15, 30 and 50 years of age, and at baseline (mean age=60)). Participants were followed-up in the Swedish National Inpatient Register for ascertainment of AF. Cox proportional hazards regression models were used to estimate relative risks (RR) with 95% CIs, adjusted for potential confounders.Results During a median follow-up of 12 years, 4568 cases of AF were diagnosed. We observed a RR of 1.19 (95% CI 1.05 to 1.36) of developing AF in men who at the age of 30 years had exercised for >5 h/week compared with 5 h/week at age 30 and quit exercising later in life (1 h/day vs almost never) and the association was similar after excluding men with previous coronary heart disease or heart failure at baseline (corresponding RR 0.88, 95% CI 0.77 to 0.998).Conclusions Leisure-time exercise at younger age is associated with an increased risk of AF, whereas walking/bicycling at older age is associated with a decreased risk.