The Role of Ceramide 1-Phosphate in Inflammation, Cellular Proliferation, and Wound Healing
The Role of Ceramide 1-Phosphate in Inflammation, Cellular Proliferation, and Wound Healing
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DOI：
10.1007/978-3-030-21162-2_5
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Chalfant, Charles E.
中科院分区：
文献类型：
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作者：
Berwick, Melissa L.;Dudley, Brittany A.;Chalfant, Charles E.
磷酸鞘脂，神经酰胺1-磷酸（C1 P），长期以来一直被认为是一种动态的生物活性剂。二十多年的研究已经开始表征C1 P的各种调节作用，从哺乳动物炎症反应和伤口愈合到细胞增殖和存活。作为复杂平衡的“鞘脂变阻器”的代谢产物，C1 P是上游和下游机制的重要生理调节剂。本章作为一个概述的既定和牵连的作用C1 P在细胞过程中至关重要的疾病和哺乳动物的生理。此外，我们还讨论了C1 P在癌症治疗、伤口治疗和疾病前诊断中的潜在临床作用。虽然关于C1 P代谢和这种生物活性脂质靶向的信号传导因子的程度仍然存在许多问题，但新技术和方法显示出识别C1 P调节的关键靶点，信号传导途径和生理学的巨大希望。
The phospho-sphingolipid, ceramide 1-phosphate (C1P), has long been implicated as a dynamic bioactive agent. Over two decades of research has begun to characterize various regulatory roles for C1P from mammalian inflammatory response and wound healing to cellular proliferation and survival. As a metabolite of the intricately balanced "sphingolipid rheostat", C1P stands as a crucial physiological regulator of both upstream and downstream mechanisms. This chapter serves as an overview of established and implicated roles for C1P in cellular processes vital to diseases and mammalian physiology. Additionally, we discuss potential clinical roles for C1P in cancer treatment, wound therapy, and pre-disease diagnosis. While many questions remain regarding C1P metabolism and the extent of signaling factors targeted by this bioactive lipid, new technologies and methodologies show great promise to discern key targets, signaling pathways, and physiologies regulated by C1P.