Associations between IgG antibody to oral organisms and carotid intima-medial thickness in community-dwelling adults
Associations between IgG antibody to oral organisms and carotid intima-medial thickness in community-dwelling adults
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DOI：
10.1016/j.atherosclerosis.2005.03.017
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发表时间：
2005-12-01
期刊：
影响因子：
5.3
通讯作者：
Offenbacher, S
中科院分区：
文献类型：
--
作者：
Beck, JD;Eke, P;Offenbacher, S
目的：本研究的目的是描述17个口腔微生物和动脉粥样硬化的IgG抗体之间的关系，指数颈动脉内膜-中壁厚度（IMT）和评估吸烟的作用。方法和结果：我们的研究是基于一个子集的参与者在社区动脉粥样硬化的风险（ARIC）研究，谁收到了完整的牙周检查在访问4（1996-1998）。结果B超评估平均颈动脉IMT >= 1 mm。暴露的血清IgG抗体水平对17牙周微生物使用全细菌棋盘免疫印迹技术。对所有17种抗体的评价表明，直弯杆菌抗体导致最佳拟合模型（OR = 2.3，95%CI = 1.83-2.84）和具有高C.腹直肌和消化链球菌微滴度的IMT >= 1 mm的患病率几乎是仅高C的患者的两倍。腹直肌抗体阳性率分别为8.3%和16.3%。按吸烟分层表明，除牙龈卟啉单胞菌外，所有对吸烟者显着的微生物模型对从不吸烟者也显着（p = 0.08）。结论：这是第一项报告口腔生物反应性IgG抗体与亚临床动脉粥样硬化之间关系的研究，在曾经吸烟者和从不吸烟者中，这种关系都很明显。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Aims: The aims of this study are to describe the relationships between IgG antibodies to 17 oral organisms and atherosclerosis as indexed by carotid intima-medial wall thickness (IMT) and to evaluate the role of smoking.Methods and results: Our study is based on a subset of participants in the Atherosclerosis Risk in Communities (ARIC) Study, who received a complete periodontal examination during visit 4 (1996-1998). The Outcome was mean carotid IMT >= 1 mm assessed by B-mode ultrasound. The exposures were serum IgG antibody levels against 17 periodontal organisms using a whole bacterial checkerboard immunoblotting technique. Evaluation of all 17 antibodies indicated that antibody to Campylobacter rectus resulted in the best-fitting model (OR = 2.3, 95% Cl = 1.83-2.84) and individuals with both high C. rectus and Peptostreptococcus micros titers had almost twice the prevalence of IMT >= 1 mm than those with only a high C. rectus antibody (8.3% versus 16.3%). Stratification by smoking indicated that all microbial models significant for smokers were also significant for never smokers except for Porphyromonas gingivalis (p = 0.08).Conclusions: This is the first study to report a relationship between IgG antibody reactive to oral organisms and subclinical atherosclerosis with significant relationships evident in both ever and never smokers. (c) 2005 Elsevier Ireland Ltd. All rights reserved.