Preparation of complex nano-particles based on alginic acid/poly[(2-dimethylamino) ethyl methacrylate] and a drug vehicle for doxorubicin release controlled by ionic strength
Preparation of complex nano-particles based on alginic acid/poly[(2-dimethylamino) ethyl methacrylate] and a drug vehicle for doxorubicin release controlled by ionic strength
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DOI：
10.1016/j.ejps.2011.10.020
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发表时间：
2012-01-23
影响因子：
4.6
通讯作者：
Zhang, Liping
中科院分区：
文献类型：
--
作者：
Cai, Hong;Ni, Caihua;Zhang, Liping
以海藻酸（ALG-H）和聚[（2-二甲氨基）甲基丙烯酸乙酯]（PDEMA）为原料，在不添加任何表面活性剂和添加剂的情况下，在纯水中简单混合合成单分散复合纳米颗粒。对纳米颗粒的结构和性能进行了广泛的研究。ALG-H和PDEMA的组成不同，纳米粒子的表面电荷和平均尺寸也不同。纳米粒子是通过静电引力形成的，在纯水中非常稳定，但在盐溶液中解离。一种抗癌药物（阿霉素）被装载在纳米颗粒中，并在不同的盐水溶液中释放。释放谱显示，药物释放可以通过调节pH和盐浓度来控制。该纳米颗粒具有制备工艺简单、成本低、不含有机溶剂、粒径可控、可生物降解和生物相容性好等明显的优点。(C) 2011 Elsevier BM。版权所有。
Monodispersed complex nano-particles were synthesized simply by mixing alginic acid (ALG-H) with poly[(2-dimethylamino) ethyl methacrylate] (PDEMA) in pure water without any surfactants or additives. The structure and properties of the nano-particles were extensively studied. The surface charges and average sizes of the nano-particles were varied with the composition of ALG-H and PDEMA. The nano-particles were formed through electrostatic attraction force, and they were very stable in pure water, but dissociated in salt solutions. An anticancer drug (doxorubicin) was loaded in the nanoparticles and released in different saline solutions. The release profiles revealed that the drug release could be controlled by adjusting the pH and salt concentrations. The nano-particles displayed apparent advantages such as simple preparation process, low cost, free of organic solvents, size controllable, biodegradable and biocompatible. (C) 2011 Elsevier BM. All rights reserved.