UNC-6, A LAMININ-RELATED PROTEIN, GUIDES CELL AND PIONEER AXON MIGRATIONS IN C-ELEGANS
UNC-6, A LAMININ-RELATED PROTEIN, GUIDES CELL AND PIONEER AXON MIGRATIONS IN C-ELEGANS
复制标题
DOI：
10.1016/0896-6273(92)90240-e
复制
发表时间：
1992-11-01
期刊：
影响因子：
16.2
通讯作者：
HEDGECOCK, EM
中科院分区：
文献类型：
--
作者：
ISHII, N;WADSWORTH, WG;HEDGECOCK, EM
unc-6基因是引导先锋轴突和细胞沿体壁沿着迁移所必需的。优雅的在突变体中，背侧和腹侧迁移被中断，但纵向运动基本上不受影响。通过两个独立的转座子插入标记该基因用于分子克隆。基于基因组和cDNA测序，该基因编码一种新的层粘连蛋白相关蛋白，α-6（591个氨基酸）。N-末端与N-末端同源（即，结构域VI、V-1、V-2和V-3），而C-末端是独特的结构域。我们建议，α-6是细胞外基质的一个组成部分的线索，引导背腹迁移的表皮。
The unc-6 gene is required for the guidance of pioneer axons and migrating cells along the body wall in C. elegans. In mutants, dorsal and ventral migrations are disrupted, but longitudinal movements are largely unaffected. The gene was tagged for molecular cloning by two independent transposon insertions. Based on genomic and cDNA sequencing, the gene encodes a novel laminin-related protein, UNC-6 (591 amino acids). The N-terminus is homologous to the N-termini (i.e., domains VI, V-1, V-2, and V-3) of laminin subunits, while the C-terminus is a unique domain. We propose that UNC-6 is a component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis.