Severe falciparum malaria in Gabonese children: clinical and laboratory features
Severe falciparum malaria in Gabonese children: clinical and laboratory features
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DOI：
10.1186/1475-2875-4-1
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发表时间：
2005-01-01
期刊：
影响因子：
3
通讯作者：
Kombila, M
中科院分区：
文献类型：
--
作者：
Dzeing-Ella, A;Obiang, PCN;Kombila, M
背景：疟疾每年继续夺去100万至200万人的生命，主要是撒哈拉以南非洲的儿童。死亡率的降低部分取决于医院护理质量的提高、保健工作者的培训和公共卫生的改善。本研究探讨了严重的恶性疟疾在加蓬children.Methods的预后指标：一项观察性研究，研究严重疟疾的临床表现和实验室特征进行了两年多的中心医院利伯维尔，加蓬。结果：重症恶性疟患儿年龄多在5岁以下（92.3%），其中10岁以下的患儿有恶性疟原虫感染，有1种或多种重症疟疾表现。贫血是严重疟疾最常见的特征（占病例的67.8%），其次是呼吸窘迫（31%）、脑型疟疾（24%）、高乳酸血症（16%）和低血糖（10%）。贫血多见于18个月以下的儿童，而脑型疟疾多见于18个月以上的儿童。总病死率为9%。预后指标与最高的病死率昏迷/癫痫发作，高乳酸血症和低血糖，最高的病死率是在儿童与所有这三个features.Conclusions：及时和适当的，分类和治疗疟疾有助于确定最严重的疾病儿童和艾滋病早期和适当的管理的严重疾病的儿童。
Background: Malaria continues to claim one to two million lives a year, mainly those of children in sub-Saharan Africa. Reduction in mortality depends, in part, on improving the quality of hospital care, the training of healthcare workers and improvements in public health. This study examined the prognostic indicators of severe falciparum malaria in Gabonese children.Methods: An observational study examining the clinical presentations and laboratory features of severe malaria was conducted at the Centre Hospitalier de Libreville, Gabon over two years. Febrile children aged from 0 to 10 years with Plasmodium falciparum infection and one or more features of severe malaria were enrolled.Results: Most children presenting with severe falciparum malaria were less than 5 years (92.3% of 583 cases). Anaemia was the most frequent feature of severe malaria (67.8% of cases), followed by respiratory distress (31%), cerebral malaria (24%) hyperlactataemia (16%) and then hypoglycaemia (10%). Anaemia was more common in children under 18 months old, while cerebral malaria usually occurred in those over 18 months. The overall case fatality rate was 9%. The prognostic indicators with the highest case fatality rates were coma/seizures, hyperlactataemia and hypoglycaemia, and the highest case fatality rate was in children with all three of these features.Conclusions: Prompt and appropriate, classification and treatment of malaria helps identify the most severely ill children and aids early and appropriate management of the severely ill child.