Alveolar Macrophages
Alveolar Macrophages
复制标题
DOI：
10.1016/j.cellimm.2018.01.005
复制
发表时间：
2018-08-01
影响因子：
4.3
通讯作者：
Misharin, Alexander V.
中科院分区：
文献类型：
--
作者：
Joshi, Nikita;Walter, James M.;Misharin, Alexander V.
肺泡巨噬细胞是远端肺实质中最丰富的先天免疫细胞，位于肺泡腔表面。它们首先遇到入侵的病原体和污染物，并帮助协调肺部免疫反应的启动和解决。与其他组织内巨噬细胞类似，肺泡巨噬细胞也具有非免疫、组织特异性、稳态功能，最显著的是清除表面活性剂。在这篇综述中，我们将讨论个体发生和局部肺环境如何塑造肺泡巨噬细胞在健康和疾病中的作用。
Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.