The TRANSPARENT TESTA GLABRA1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat protein
The TRANSPARENT TESTA GLABRA1 locus, which regulates trichome differentiation and anthocyanin biosynthesis in Arabidopsis, encodes a WD40 repeat protein
复制标题
DOI：
10.1105/tpc.11.7.1337
复制
发表时间：
1999-07-01
期刊：
影响因子：
11.6
通讯作者：
Gray, JC
中科院分区：
文献类型：
--
作者：
Walker, AR;Davison, PA;Gray, JC
透明种皮GLABRA1（TTG1）基因座调节拟南芥中的几种发育和生化途径，包括叶、茎和根上毛的形成，以及种子粘液和花青素色素的产生。TTG1基因座已被分离的定位克隆，其身份得到证实，通过互补的TTG1突变体。该基因座编码341个氨基酸残基的蛋白质，具有4个WD 40重复序列。该蛋白类似于AN11，一种矮牵牛花色素苷生物合成的调节剂，并且与异源三聚体G蛋白的β亚基的那些更远地相关，这表明TTG1在信号转导到下游转录因子中的作用。1.5 kb TTG1转录本存在于拟南芥的所有主要器官中。六个突变等位基因的序列分析已经确定了TTG1蛋白中产生截短或单个氨基酸变化的碱基变化。
The TRANSPARENT TESTA GLABRA1 (TTG1) locus regulates several developmental and biochemical pathways in Arabidopsis, including the formation of hairs on leaves, stems, and roots, and the production of seed mucilage and anthocyanin pigments. The TTG1 locus has been isolated by positional cloning, and its identity was confirmed by complementation of a ttg1 mutant. The locus encodes a protein of 341 amino acid residues with four WD40 repeats. The protein is similar to AN11, a regulator of anthocyanin biosynthesis in petunia, and more distantly related to those of the beta subunits of heterotrimeric G proteins, which suggests a role for TTG1 in signal transduction to downstream transcription factors. The 1.5-kb TTG1 transcript is present in all major organs of Arabidopsis. Sequence analysis of six mutant alleles has identified base changes producing truncations or single amino acid changes in the TTG1 protein.