Habitual coffee consumption and risk of cognitive decline/dementia: A systematic review and meta-analysis of prospective cohort studies
Habitual coffee consumption and risk of cognitive decline/dementia: A systematic review and meta-analysis of prospective cohort studies
复制标题
习惯性喝咖啡与认知能力下降/痴呆的风险：前瞻性队列研究的系统回顾和荟萃分析
DOI：
10.1016/j.nut.2015.11.015
复制
发表时间：
2016-06-01
期刊：
影响因子：
4.4
通讯作者：
Xu, Yun
中科院分区：
文献类型：
--
作者：
Liu, Qing-Ping;Wu, Yan-Feng;Xu, Yun
目的：关于咖啡摄入量和认知能力下降或痴呆风险的流行病学研究结果尚无定论。本研究的目的是对前瞻性研究进行荟萃分析，以评估咖啡消费与认知能力下降和痴呆风险之间的关联。方法：通过搜索 1966 年至 2014 年 12 月期间的 PubMed 和 Embase 数据库来确定相关研究。报告咖啡消费与痴呆发病率或认知变化之间关系的相对风险 (RR) 和 95% 置信区间 (CI) 的前瞻性队列符合资格。研究特定的 RR 通过使用随机效应模型进行组合。结果：荟萃分析中纳入了 11 项前瞻性研究，其中包括 29,155 名参与者。综合 RR 表明，高咖啡摄入量与认知能力下降或痴呆的不同指标无关（总结 RR，0.97；95% CI，0.84-1.11）。亚组分析表明，最高咖啡摄入量与阿尔茨海默病风险之间存在显着的负相关（总结 RR，0.73；95% CI，0.55-0.97）。包括八项研究在内的剂量反应分析并未显示咖啡摄入量的增加与认知能力下降或痴呆风险之间存在关联（每天摄入咖啡量增加 1 杯；总结 RR，1.00；95% CI，0.98-1.02）。结论：本研究表明，较高的咖啡摄入量与阿尔茨海默病风险降低相关。需要进一步的随机对照试验或精心设计的队列研究来确定咖啡消费与认知能力下降或痴呆之间的关联。 (C) 2016 Elsevier Inc. 保留所有权利。
Objective: Findings from epidemiologic studies of coffee consumption and risk for cognitive decline or dementia are inconclusive. The aim of this study was to conduct a meta-analysis of prospective studies to assess the association between coffee consumption and the risk for cognitive decline and dementia.Methods: Relevant studies were identified by searching PubMed and Embase databases between 1966 and December 2014. Prospective cohorts that reported relative risk (RRs) and 95% confidence intervals (CIs) for the association of coffee consumption with dementia incidence or cognitive changing were eligible. Study-specific RRs were combined by using a random-effects model.Results: Eleven prospective studies, including 29,155 participants, were included in the meta analysis. The combined RR indicated that high coffee consumption was not associated with the different measures of cognitive decline or dementia (summary RR, 0.97; 95% CI, 0.84-1.11). Subgroup analyses suggested a significant inverse association between highest coffee consumption and the risk for Alzheimer disease (summary RR, 0.73; 95% CI, 0.55-0.97). The dose-response analysis, including eight studies, did not show an association between the increment of coffee intake and cognitive decline or dementia risk (an increment of 1 cup/d of coffee consumed; summary RR, 1.00; 95% CI, 0.98-1.02).Conclusions: The present study suggests that higher coffee consumption is associated with reduced risk for Alzheimer disease. Further randomized controlled trials or well-designed cohort studies are needed to determine the association between coffee consumption and cognitive decline or dementia. (C) 2016 Elsevier Inc. All rights reserved.