Perspectives on FIV vaccine development
Perspectives on FIV vaccine development
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DOI：
10.1016/s0264-410x(97)00056-x
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发表时间：
1997-08-01
期刊：
影响因子：
5.5
通讯作者：
Yamamoto, JK
中科院分区：
文献类型：
--
作者：
Elyar, JS;Tellier, MC;Yamamoto, JK
猫免疫缺陷病毒(FIV)是十年前发现的猫免疫缺陷综合征(FAIDS)的病原体，FAIDS是家猫的一种慢性退行性、致死性疾病，我们对FIV的免疫发病机制的了解有所提高，但有效的治疗和预防措施的开发一直很缓慢，反映了该病毒对模式医学干预的非凡适应性。FIV疫苗开发的成功和失败与人类免疫缺陷病毒(HIV)疫苗研究中遇到的成功和失败类似。本文综述了FIV/疫苗的研究现状，包括常规疫苗、重组亚单位疫苗和重组载体疫苗的试验，以及疫苗保护的潜在机制，从FIV/模型中吸取的经验教训将为HIV/疫苗的发展提供新的见解。(C)1997年爱思唯尔科学有限公司。
Feline immunodeficiency virus (FIV), discovered a decade ago, is the causative agent of feline immunodeficiency syndrome (FAIDS), a chronically degenerative, fatal disease in domestic cats, Our understanding of the immunopathogenesis of FIV has improved but the development of an effective therapy and prophylaxis has been slow, reflecting the remarkable adaptability of the virus to model medical intervention. FIV vaccine development has had its successes and failures similar to those encountered in human immunodeficiency virus (HIV) vaccine research. This review summarizes the status of FIV/vaccine research, including trials of conventional, recombinant subunit and recombinant vector-based vaccines, and potential mechanisms of vaccine protection, The lessons learned from the FIV/model should provide new insights for the approaches toward the development of HIV/vaccines. (C) 1997 Elsevier Science Ltd.