Synthesis of catechins via thiourea/AuCl3-catalyzed cycloalkylation of aryl epoxides
Synthesis of catechins via thiourea/AuCl3-catalyzed cycloalkylation of aryl epoxides
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硫脲/AuCl3催化芳基环氧化物环烷基化合成儿茶素
DOI：
10.1021/jo8005649
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发表时间：
2008-06-20
影响因子：
3.6
通讯作者：
Yang, Zhen
中科院分区：
文献类型：
--
作者：
Liu, Yongxiang;Li, Xiben;Yang, Zhen
在温和的条件下，通过硫脲/AuCl3/AgOTf催化的芳基环氧化物的环化反应，实现了一种面向多样性的合成结构多样化的儿茶素的方法。这一新方案提供了一个高效进入儿茶素衍生天然产物库的途径，特别是抗艾滋病毒试剂8-C-抗坏血酸-(-)-表没食子儿茶素。
A diversity-oriented approach for the synthesis of structurally diverse catechins was achieved in good yields via thiourea/AuCl3/AgOTf-catalyzed annulations of aryl epoxides under mild conditions. This new protocol provides a highly efficient entry to a library of catechins-derived natural products, notably anti-HIV, agent 8-C-ascorbyl-(-)-epigallocatechin.