CUTANEOUS FACTORS RELATED TO THE RISK OF MALIGNANT-MELANOMA
CUTANEOUS FACTORS RELATED TO THE RISK OF MALIGNANT-MELANOMA
复制标题
DOI：
10.1111/j.1365-2133.1983.tb07077.x
复制
发表时间：
1983-01-01
影响因子：
10.3
通讯作者：
MILTON, G
中科院分区：
文献类型：
--
作者：
BERAL, V;EVANS, S;MILTON, G
In a case-control study, 287 women with malignant melanoma were compared with 574 age-matched controls. Red hair color at age 5 yr was associated with a tripling of risk [relative risk (RR) = 3.0], blonde hair with a 60% increase (RR = 1.6) and fair skin with a doubling (RR = 2.1). Women with melanoma also reported that they tended to burn (RR = 1.4) and to freckle (RR = 1.9) after exposure to sunlight. Since fair skin, red hair, and the tendency to burn or freckle after exposure to sunlight all cluster in the same individuals, the extent to which each of these factors had an independent influence on susceptibility to melanoma was investigated. Hair color, especially red hair, proved to be the major determinant, followed by skin color. The reporting of above average numbers of nevi on the body was as strong a predictor of melanoma as was red hair color (RR = 3.4). A history of psoriasis was also more common in cases than controls (RR = 3.0) as was a history of vitiligo (RR = 1.8). A history of acne appeared to be protective (RR = 0.4) as did a history suggestive of chloasma (RR = 0.6) and premature graying of the hair (RR = 0.6). These relationships were irrespective of hair and skin color.
