A Minority of Patients with Rheumatoid Arthritis Show a Dominant Rearrangement of T‐Cell Receptor β Chain Genes in Synovial Lymphocytes
A Minority of Patients with Rheumatoid Arthritis Show a Dominant Rearrangement of T‐Cell Receptor β Chain Genes in Synovial Lymphocytes
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少数类风湿关节炎患者滑膜淋巴细胞中 T 细胞受体 β 链基因发生显性重排
DOI：
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发表时间：
1987
影响因子：
3.7
通讯作者：
I. Roitt
中科院分区：
文献类型：
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作者：
C. Savill;P. Delves;D. Kioussis;P. Walker;P. Lydyard;B. Colaco;M. Shipley;I. Roitt
从类风湿关节炎患者的滑液和外周血中分离的T淋巴细胞的克隆性通过T细胞抗原受体β链基因重排的限制性酶切片段图谱来证实。3例患者在其滑液T细胞中显示出显性重排，这在其外周血T细胞群中未观察到，表明存在显性T细胞克隆。然而，大多数检查的患者（11例中的8例）在滑液和外周血中均显示多克隆T细胞群。在研究的四种滑液T细胞系中，一种显示出显性T细胞克隆的证据。
The clonality of T lymphocytes isolated from the synovial fluid and peripheral blood of patients with rheumatoid arthritis was investigatcd by restriction enzyme fragment mapping of the rearrangement is of the β chain gene of the T‐cell antigen receptor. Three patients showed a dominant rearrangement amongst their synovial fluid T cells which was not seen in their peripheral blood T‐cell population, suggesting the prescnce of a predominating T‐cell clone. However, most of the patients examined (8 out of 11) demonstrated polyclonal T‐cell populations in both their synovial fluid and peripheral blood. Of four synovial fluid T‐cell lines investigated, one showed evidence of a dominant T‐cell clone.