Inferior colliculus lesions impair eyeblink conditioning in rats
Inferior colliculus lesions impair eyeblink conditioning in rats
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DOI：
10.1101/lm.716107
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发表时间：
2007-12-01
影响因子：
2
通讯作者：
Hubbard, Erin M.
中科院分区：
文献类型：
--
作者：
Freeman, John H.;Halverson, Hunter E.;Hubbard, Erin M.
获得和保持眨眼条件反射所必需的神经可塑性已经定位于小脑。然而，小脑的感觉输入来源是建立学习相关的可塑性所必需的，尚未完全确定。下丘可能是通过其投射到内侧听觉丘脑的小脑感觉输入的来源。内侧听觉丘脑是大鼠眨眼条件反射所必需的，并投射到脑桥外侧核，脑桥外侧核再投射到小脑核和皮质。本实验探讨了听觉眨眼条件反射中下丘的作用。大鼠给予双侧或单侧（对侧的条件眼）的下丘病变前10天的延迟眨眼条件与音CS。双侧或单侧病变的大鼠表现出同等受损的收购。对侧下丘的损伤程度与几项条件反射措施相关。研究结果表明，对侧下丘提供听觉输入小脑是必要的眨眼条件反射。
The neural plasticity necessary for acquisition and retention of eyeblink conditioning has been localized to the cerebellum. However, the sources of sensory input to the cerebellum that are necessary for establishing learning-related plasticity have not been identified completely. The inferior colliculus may be a source of sensory input to the cerebellum through its projection to the medial auditory thalamus. The medial auditory thalamus is necessary for eyeblink conditioning in rats and projects to the lateral pontine nuclei, which then project to the cerebellar nuclei and cortex. The current experiment examined the role of the inferior colliculus in auditory eyeblink conditioning. Rats were given bilateral or unilateral (contralateral to the conditioned eye) lesions of the inferior colliculus prior to 10 d of delay eyeblink conditioning with a tone CS. Rats with bilateral or unilateral lesions showed equivalently impaired acquisition. The extent of damage to the contralateral inferior colliculus correlated with several measures of conditioning. The findings indicate that the contralateral inferior colliculus provides auditory input to the cerebellum that is necessary for eyeblink conditioning.