Recent advances in microscale extraction driven by ion concentration polarization
Recent advances in microscale extraction driven by ion concentration polarization
复制标题
离子浓差极化驱动的微尺度萃取的最新进展
DOI：
10.1016/j.trac.2022.116537
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Anand, Robbyn K.
中科院分区：
文献类型：
--
作者：
Krishnamurthy, Aparna;Anand, Robbyn K.
微规模提取提供了几个明显的优势，包括增加样品通量，特异性和效率的实验室规模的过程。这些属性可以用来提高检测的效率，放大传感器中的分析物信号或纯化样品。最近，电动微萃取技术已经获得了越来越多的关注，由于优点，如控制质量传输，易于驱动，和便携性，这使得它们可以很容易地纳入到微型和即时护理设备。离子浓差极化（ICP）连续地产生可以驱动动电聚焦的电场梯度。虽然大多数关于ICP的文章都讨论了分析物的预浓缩，但很少有人冒险进行随后的提取步骤-分离到另一相中。这篇综述的总体目标是讨论ICP促进的微流体萃取方法的最新发展及其进一步发展的潜力。用于实现不同类别的分析物的ICP介导的提取的基本策略进行了讨论。
Microscale extraction offers several distinct advantages over bench-scale processes including increases in sample throughput, specificity, and efficiency. These attributes can be harnessed to improve the efficacy of assays, amplify analyte signals in sensors or purify samples. Recently, electrokinetic microextraction techniques have garnered increased attention owing to advantages such as control over mass transport, ease of actuation, and portability, which allow them to be readily incorporated into microscale and point-of-care devices. Ion concentration polarization (ICP) continuously creates an electric field gradient that can drive electrokinetic focusing. While the majority of articles on ICP have deliberated on analyte preconcentration, very few have ventured the subsequent extraction step – separation into another phase. The overarching aim of this review is to discuss recent developments in microfluidic extraction methods facilitated by ICP and the potential for their further advancement. Fundamental strategies used to achieve ICP-mediated extraction of distinct classes of analytes are discussed.