Small‐for‐size liver transplanted into larger recipient: A model of hepatic regeneration
Small‐for‐size liver transplanted into larger recipient: A model of hepatic regeneration
复制标题
将小型肝脏移植到较大的受体中：肝再生模型
DOI：
10.1002/hep.1840190131
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发表时间：
1993
期刊：
影响因子：
13.5
通讯作者：
T. Starzl
中科院分区：
文献类型：
--
作者：
A. Francavilla;Qihua Zeng;L. Polimeno;B. Carr;Dantong Sun;K. Porter;D. V. Van Thiel;T. Starzl
Orthotopic liver transplantation was performed in 60 recipient rats weighing 200 to 250 gm. Sixty rats of the same strain were used as liver donors, 30 weighing 100 to 140 gm (small for size) and the other 30 weighing 200 to 250 gm (same size). After 1, 2, 3, 4, 7 and 14 days (n = 5 each) DNA synthesis, nuclear thymidine labeling and mitoses were increased in both the small‐for‐size and same‐size groups, but significantly more in the former. These changes were maximal after 48 to 72 hr, similar to but later than the well‐known regeneration response after partial hepatectomy, which peaks at 24 hr in rats. Indirect indexes of regeneration of the transplanted livers also were measured: plasma or serum ornithine decarboxylase; insulin and glucagon serum levels; estradiol and testosterone serum levels (and their nuclear and cytosolic receptors); and transforming growth factor‐ß, c‐Ha‐ras and c‐jun mRNA expressions. With the small‐for‐size transplantation, these followed the same delayed pattern as the direct regeneration parameters. The small livers gradually increased in size over the course of 1 to 2 wk and achieved a volume equal to that of the liver originally present in the recipient. In contrast, no significant liver weight gain occurred in the transplanted livers from same‐size donors despite the evidence of regeneration by direct indexes, but not by most of the surrogate parameters, including ornithine decarboxylase. (Hepatology 1993;19:210–216).
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FK 506、环孢菌素和雷帕霉素对体外和体内肝脏生长的影响。
影响因子：
0.9
作者：
Francavilla,A;Starzl,TE;Carr,B;Azzarone,A;Carrieri,G;Zeng,QH;Porter,KA
通讯作者：
Porter,KA
影响因子：
29.4
作者：
D. H. V. Thiel;Judith S. Gavaler;Igal Kam;A. Francavilla;L. Polimeno;R. R. Schade-R.;J. Smith;W. Diven;R. Penkrot;T. Starzl
通讯作者：
D. H. V. Thiel;Judith S. Gavaler;Igal Kam;A. Francavilla;L. Polimeno;R. R. Schade-R.;J. Smith;W. Diven;R. Penkrot;T. Starzl
再生大鼠肝脏：胰岛素和胰高血糖素血清水平和受体结合。
影响因子：
4.8
作者：
Pezzino,V;Vigneri,R;Cohen,D;Goldfine,ID
通讯作者：
Goldfine,ID
DOI：
10.1073/pnas.85.5.1539
发表时间：
1988-03-01
影响因子：
11.1
作者：
BRAUN, L;MEAD, JE;FAUSTO, N
通讯作者：
FAUSTO, N
人 FKBP（FK506 和雷帕霉素的结合蛋白）对狗的保肝特性。
影响因子：
6.2
作者：
Starzl,TE;Schreiber,SL;Albers,MW;Porter,KA;Foglieni,CS;Francavilla,A
通讯作者：
Francavilla,A