Neisseria gonorrhoeae induces focal polymerization of actin in primary human urethral epithelium
Neisseria gonorrhoeae induces focal polymerization of actin in primary human urethral epithelium
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DOI：
10.1128/iai.66.7.3416-3419.1998
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发表时间：
1998-07-01
影响因子：
3.1
通讯作者：
Apicella, MA
中科院分区：
文献类型：
--
作者：
Giardina, PC;Williams, R;Apicella, MA
致病性奈瑟菌属会诱导永生化细胞系中的细胞骨架重组。在 Chang 结膜上皮和 T84 肠上皮中，观察到细菌接触上皮表面的局部细胞骨架重排。我们发现肌动蛋白足迹是在淋球菌攻击的初级尿道上皮中诱导的。此外，微生物诱导微绒毛从上皮细胞表面延伸。我们的结果表明，肌动蛋白足迹的形成并不是常用永生化细胞系的产物。
The pathogenic Neisseria species induce cytoskeletal reorganization in immortalized cell lines. In Chang conjunctival epithelium and T84 intestinal epithelium, focal cytoskeletal rearrangements in which bacteria contacted the epithelial surface were observed. We show that actin footprints are induced in gonococcus-challenged primary urethral epithelium. Moreover, the microbes induced microvillus extension from the epithelial cell surface. Our results indicate that formation of actin footprints is not an artifact of commonly used immortalized cell lines.